Selenoprotein N Activators
Selenoprotein N (SEPN1) Activators are a suite of compounds that bolster the functionality of SEPN1 by modulating the cellular redox state and selenium bioavailability. Compounds such as Ebselen and Diphenyl diselenide provide organic selenium, which is essential for the catalytic activity of SEPN1, a protein known to confer protection against oxidative damage in muscle cells. Methylseleninic acid and Selenomethionine, by serving as selenium donors, ensure the adequate presence of this trace element for SEPN1 synthesis and function. Selenocysteine, often termed the 21st amino acid, is integral to SEPN1's structure, directly contributing to its enzymatic action. Sodium selenite, as an inorganic selenium source, and L-selenohomocysteine further support SEPN1's antioxidant defense role by providing the necessary selenium for the protein's biosynthesis.
In addition to selenium compounds, activators like N-acetyl-L-cysteine enhance SEPN1's functionality by contributing to glutathione levels, a cofactor for the protein's peroxidase-like activity. Vitamins such as Alpha-tocopherol and Ascorbic acid act synergistically with SEPN1, reducing the oxidative burden that the protein must manage, thereby preserving its function. Glutathione directly sustains SEPN1 activity by maintaining the protein in its reduced, active state. Beta-carotene, as an antioxidant, supports the overall network in which SEPN1 operates, reducing oxidative stress and allowing SEPN1 to perform its role in antioxidant defense more efficiently.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
Ebselen, an organoselenium compound, mimics glutathione peroxidase activity. By reducing oxidative stress, it can indirectly enhance Selenoprotein N function, which is known to protect against oxidative damage in muscle cells. | ||||||
L-Selenomethionine | 3211-76-5 | sc-204050 sc-204050A | 250 mg 1 g | $223.00 $597.00 | 1 | |
Selenomethionine serves as a nutritional supplement that provides selenium. It enhances Selenoprotein N by being incorporated nonspecifically into proteins in place of methionine, indirectly increasing the functional pool of the protein. | ||||||
Sodium selenite | 10102-18-8 | sc-253595 sc-253595B sc-253595C sc-253595A | 5 g 500 g 1 kg 100 g | $49.00 $183.00 $316.00 $98.00 | 3 | |
Sodium selenite is a common form of selenium supplementation. It enhances Selenoprotein N by providing the essential selenium needed for its biosynthesis and proper function in antioxidant defense. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-acetyl-L-cysteine contributes to glutathione synthesis, a cofactor necessary for the proper function of Selenoprotein N. It indirectly supports the protein's antioxidant capacity in muscle tissues. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B sc-214454C | 10 g 25 g 100 g 1 kg | $43.00 $62.00 $141.00 $430.00 | ||
Alpha-tocopherol, a form of vitamin E, acts synergistically with Selenoprotein N in protecting cell membranes from oxidative damage. It enhances the protein's activity by reducing the oxidative burden that Selenoprotein N needs to manage. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic acid regenerates other antioxidants like vitamin E, indirectly supporting the function of Selenoprotein N. It contributes to the overall antioxidant defense system where Selenoprotein N is active. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $82.00 $2091.00 | 8 | |
Glutathione directly supports the activity of Selenoprotein N by acting as a reducing agent in the glutathione peroxidase-like activity of the protein. This maintains the protein in its active form to carry out antioxidant functions. | ||||||
β-Carotene | 7235-40-7 | sc-202485 sc-202485A sc-202485B sc-202485C | 1 g 25 g 50 g 5 kg | $80.00 $351.00 $621.00 $12791.00 | 5 | |
Beta-carotene is a precursor to vitamin A and an antioxidant that operates within the antioxidant network, which includes Selenoprotein N. It helps maintain the protein's activity by reducing the overall oxidative load in cells. | ||||||