Selenoprotein N Inhibitors
Chemical inhibitors of Selenoprotein N act through various mechanisms to inhibit its function. Phosphoramidon, by inhibiting neprilysin, indirectly leads to alterations in calcium homeostasis which is a critical aspect of Selenoprotein N function. Thimerosal, an organomercury compound, targets the selenium-containing active sites of selenoproteins, directly inhibiting the antioxidative functions of Selenoprotein N. Auranofin, a gold-containing inhibitor of thioredoxin reductase, also targets the selenocysteine in the active site of Selenoprotein N, leading to the inhibition of its redox-regulatory function. Cadmium chloride, a heavy metal, can bind to and inhibit metalloproteins like Selenoprotein N, disrupting metal ion balance and affecting the protein's functional integrity.
Arsenic trioxide and Lead acetate are additional heavy metal-based inhibitors that interfere with the thiol groups in proteins and calcium-dependent enzymes, respectively. Arsenic trioxide's binding to vicinal thiols can interfere with the function of thiol-containing enzymes, including Selenoprotein N, leading to its inhibition. Lead acetate, by inhibiting calcium-dependent processes, disrupts Selenoprotein N's role in calcium signaling. Primaquine, through its induction of oxidative stress, overwhelms the antioxidative capacity of Selenoprotein N, which normally acts to protect cells from oxidative damage. Methimazole impacts the oxidative metabolism regulated by thyroid hormones, altering the redox balance and inhibiting Selenoprotein N's redox-related functions. Chloroquine raises endosomal pH and inhibits lysosomal degradation, potentially affecting the protein folding machinery that Selenoprotein N is involved in, thus inhibiting its proper function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phosphoramidon | 119942-99-3 | sc-201283 sc-201283A | 5 mg 25 mg | $199.00 $632.00 | 8 | |
Phosphoramidon is a metalloprotease inhibitor that can inhibit neprilysin. Selenoprotein N is involved in calcium homeostasis and since neprilysin can modulate peptide levels that affect calcium channels, its inhibition by phosphoramidon can lead to increased cytosolic calcium levels, potentially inhibiting Selenoprotein N function in sarcoplasmic reticulum calcium regulation. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin is a gold-containing inhibitor of thioredoxin reductase. Selenoprotein N has a selenocysteine in its active site, which can be targeted by auranofin, leading to the inhibition of its redox-regulatory function. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Cadmium chloride is a heavy metal that can displace metal ions in proteins. It can bind to and inhibit metalloproteins, potentially disrupting the metal ion balance crucial for Selenoprotein N's function in maintaining cellular redox homeostasis. | ||||||
8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline | 90-34-6 | sc-483239 | 1 g | $360.00 | 1 | |
Primaquine is an 8-aminoquinoline drug that causes oxidative stress within the cell. This increase in oxidative stress can overwhelm the antioxidative capacity of Selenoprotein N, effectively inhibiting its function. | ||||||
Methimazole | 60-56-0 | sc-205747 sc-205747A | 10 g 25 g | $70.00 $112.00 | 4 | |
Methimazole is a thiourea derivative that can inhibit the synthesis of thyroid hormones. Thyroid hormones regulate oxidative metabolism, and their inhibition can alter the redox balance, which may inhibit the redox-related functions of Selenoprotein N. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic trioxide can bind to vicinal thiols, potentially interfering with the function of thiol-containing enzymes such as Selenoprotein N, leading to its inhibition. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is a 4-aminoquinoline drug that raises endosomal pH. It can inhibit lysosomal degradation, which may lead to the accumulation of misfolded proteins, affecting the protein folding machinery in which Selenoprotein N is involved and thereby inhibiting its function. | ||||||
Lead(II) Acetate | 301-04-2 | sc-507473 | 5 g | $85.00 | ||
Lead acetate is a heavy metal compound that can inhibit calcium-dependent enzymes. Selenoprotein N is involved in calcium signaling, and the inhibition of calcium-dependent processes could inhibit the proper functioning of Selenoprotein N in those pathways. | ||||||