SEC22C Activators
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol (DAG) analog which activates Protein Kinase C (PKC). PKC has been shown to phosphorylate members of the SEC22 family, which includes SEC22C, thus potentially enhancing its vesicle trafficking function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing intracellular cAMP levels, which in turn activates PKA. PKA phosphorylation can influence the SNARE complex, of which SEC22C is a part, thereby potentially enhancing its vesicle fusion capabilities. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore which raises intracellular calcium levels, a second messenger in various signaling pathways. Elevated calcium may enhance the interaction of SEC22C with other SNARE proteins, promoting vesicle fusion. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
This cAMP analog selectively activates Epac, a guanine nucleotide exchange factor for Ras-like small GTPases, which are involved in vesicle trafficking. This activation could enhance SEC22C's role in vesicular transport through the Golgi apparatus. | ||||||
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $465.00 | ||
GTPγS is a non-hydrolyzable GTP analog that can activate GTPase proteins involved in vesicle formation and trafficking. SEC22C, being a v-SNARE, may have its membrane fusion activity enhanced due to increased formation and docking of transport vesicles. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is known to inhibit certain types of protein kinases. Inhibition of competitive kinase pathways can upregulate the SNARE complex pathway by reducing negative regulatory influences, which may enhance the activity of SEC22C in vesicle trafficking. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the Golgi apparatus structure, which may lead to a compensatory upregulation of SNARE proteins like SEC22C to maintain vesicular transport functions. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is an ionophore that alters intracellular ion gradients, affecting vesicle formation and trafficking. This alteration may enhance the function of SEC22C in the secretion pathway by modulating vesicle acidification and maturation. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
NSC23766 inhibits the activation of Rac1, a small GTPase. By inhibiting Rac1, this may increase the demand for SEC22C's role in vesicle docking and fusion, as Rac1 is involved in actin cytoskeleton rearrangements affecting vesicle movement. | ||||||