SCRG1 Activators
SCRG1, also known as Scrapie Responsive Gene 1, is a protein that, in humans, is encoded by the SCRG1 gene. This gene was initially identified in a study investigating genes that were upregulated in the brains of sheep infected with the prion disease scrapie, hence its name.The SCRG1 protein is a secreted growth factor that acts through its receptor, BMPR-IB, a bone morphogenetic protein receptor. Together, they play a role in promoting the survival and growth of neural cells.it is known to be expressed in various tissues, including the heart, brain, and skeletal muscle. Its expression in the brain is particularly high during embryonic development, suggesting it may play a role in neural development. Moreover, it has been shown to stimulate neurite outgrowth, further supporting its role in nervous system development.
SCRG1 also plays a role in the regeneration of peripheral nerves. Studies have shown that SCRG1 can promote the growth of Schwann cells, which are essential for nerve regeneration, and can stimulate axonal sprouting.Understanding the functions of SCRG1 could provide valuable insights into the molecular mechanisms underlying neural development, regeneration, and potentially prion diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin induces ER stress and may indirectly influence SCRG1 activity as part of the ER stress response. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin, an ER stress inducer, can impact SCRG1 activity by affecting calcium homeostasis in the ER. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts ER-Golgi transport, potentially influencing SCRG1 activity in stress response pathways. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $41.00 $53.00 | 3 | |
4-Phenylbutyrate acts as a chemical chaperone, potentially influencing SCRG1 activity by alleviating ER stress. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
Salubrinal, a selective inhibitor of eIF2α dephosphorylation, may affect SCRG1 in the context of ER stress response. | ||||||
Guanabenz HCl | 23113-43-1 | sc-507500 | 100 mg | $241.00 | ||
Guanabenz, which affects the unfolded protein response, could potentially modulate SCRG1 activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, known for its anti-inflammatory properties, might indirectly affect SCRG1 through cellular stress pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, an antioxidant, may influence SCRG1 activity by modulating cellular stress responses. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetylcysteine, an antioxidant, could indirectly affect SCRG1 by reducing oxidative stress. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium, used in neurological disorders, might influence signaling pathways involving SCRG1. | ||||||