Sclerostin Inhibitors
Sclerostin inhibitors are a class of compounds that target a specific protein called sclerostin within the human body. Sclerostin is primarily produced by osteocytes, which are specialized cells found within bone tissue. Its primary role is to regulate bone formation by inhibiting the activity of osteoblasts, the cells responsible for building and repairing bone. Sclerostin acts as a negative regulator of bone growth and development by suppressing the Wnt/β-catenin signaling pathway, which is crucial for promoting bone formation and maintenance.
Sclerostin inhibitors work by blocking the action of sclerostin, thereby promoting bone formation and inhibiting bone resorption. These compounds are designed to bind to sclerostin molecules, preventing them from interfering with the Wnt/β-catenin pathway. As a result, osteoblasts become more active, leading to increased bone formation and improved bone density. This class of compounds has garnered significant attention in the field of bone research, as they hold the ability to address conditions characterized by low bone density and increased fracture risk, such as osteoporosis. The development and study of sclerostin inhibitors represent a promising avenue for enhancing our understanding of bone biology and exploring novel approaches to addressing bone-related disorders.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride has been shown to activate the Wnt signaling pathway, which may lead to a decrease in sclerostin expression. This activation can promote osteoblast activity and bone formation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate acts as a histone deacetylase inhibitor, potentially leading to changes in chromatin structure and gene expression. It may decrease sclerostin levels, influencing bone metabolism. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, found in the plant Coleus forskohlii, increases cyclic AMP levels, which might downregulate sclerostin expression and promote bone formation. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
This active form of vitamin D can regulate the expression of numerous genes, including those involved in bone metabolism. It has been observed to decrease sclerostin expression, potentially enhancing osteoblast activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid found in many plants, has antioxidant properties and may influence gene expression. It has the potential to reduce sclerostin levels and positively affect bone metabolism. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Found in red wine, grapes, and berries, resveratrol has antioxidant properties. It may downregulate sclerostin expression, contributing to the regulation of bone formation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a soy isoflavone, has been observed to influence gene expression. It has the potential to reduce sclerostin levels, playing a role in bone metabolism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Derived from turmeric, curcumin possesses anti-inflammatory properties. It might downregulate sclerostin expression, influencing bone homeostasis. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Simvastatin, a statin used for managing cholesterol levels, has been observed to have effects on bone metabolism. It might decrease sclerostin expression, promoting bone formation. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone, a thiazolidinedione, has been used in managing diabetes. It has potential effects on bone metabolism, possibly leading to a reduction in sclerostin expression. | ||||||