Date published: 2026-4-23

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Sclerostin Antibodies

Santa Cruz Biotechnology features a diverse variety of Sclerostin Antibodies for investigating sclerostin's role in bone metabolism. Sclerostin Antibodies are validated for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Sclerostin is a glycoprotein produced by osteocytes that plays a critical role in bone homeostasis by inhibiting the Wnt signaling pathway, which is essential for bone formation. The regulation of sclerostin is vital for maintaining bone density and strength, making it a significant target for research in osteoporosis and other bone-related disorders. Understanding sclerostin function can provide insights into therapeutic strategies for enhancing bone health. Sclerostin research has revealed important mechanisms in bone development and remodeling. Ongoing studies continue to uncover new aspects of sclerostin's involvement in skeletal disorders and potential therapeutic applications. Current investigations focus on how sclerostin influences bone mass regulation and mineral homeostasis. Santa Cruz Biotechnology monoclonal antibodies support researchers worldwide in advancing bone biology knowledge and developing innovative treatments for bone-related conditions.

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Sclerostin Antibodies

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Sclerostin Antibody (C-11)

sc-518161mouse IgM κ31-52 (h)WB, IP, IF, ELISAh
2
(1)

Sclerostin CRISPR Knockout, HDR and Double Nickase Plasmids

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Sclerostin CRISPR/Cas9 KO Plasmid (h)

sc-401527hGene KnockoutGFP0
(0)

Sclerostin Double Nickase Plasmid (h)

sc-401527-NIChGene KnockoutPuromycin0
(0)

Sclerostin Double Nickase Plasmid (h2)

sc-401527-NIC-2hGene KnockoutPuromycin0
(0)

Sclerostin CRISPR Activation Products

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Sclerostin CRISPR Activation Plasmid (h)

sc-401527-ACThGene ActivationPuro, Blast, Hygro0
(0)

Sclerostin CRISPR Activation Plasmid (m)

sc-428914-ACTmGene ActivationPuro, Blast, Hygro0
(0)

Sclerostin CRISPR Activation Plasmid (m2)

sc-428914-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

Sclerostin siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

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Sclerostin siRNA (h)

sc-61503hGene SilencingN/A0
(0)

Sclerostin shRNA Plasmid (h)

sc-61503-SHhGene SilencingPuromycin0
(0)

Sclerostin shRNA (h) Lentiviral Particles

sc-61503-VhGene SilencingPuromycin0
(0)

Sclerostin siRNA (m)

sc-61504mGene SilencingN/A
1
(0)

Sclerostin shRNA Plasmid (m)

sc-61504-SHmGene SilencingPuromycin
1
(0)

Sclerostin shRNA (m) Lentiviral Particles

sc-61504-VmGene SilencingPuromycin
1
(0)