Scc1 Inhibitors
Scc1, formally known as a cohesin subunit, is crucial for the correct functioning of the cohesin complex, a ring-shaped protein assembly that encircles sister chromatids to maintain their cohesion until the appropriate phase of cell division. This protein plays an indispensable role in ensuring accurate chromosome segregation during both mitosis and meiosis, which is fundamental to genetic stability and the prevention of aneuploidy. Beyond its pivotal role in cell division, Scc1 and the cohesin complex are intimately involved in the regulation of DNA repair and transcription, facilitating the repair of DNA double-strand breaks through homologous recombination and regulating gene expression by influencing the organization and accessibility of chromatin. The precise regulation of cohesin's association with and release from chromosomes is a finely tuned process, involving numerous other proteins and post-translational modifications, underscoring the complexity of Scc1's role in cellular physiology.
The inhibition of Scc1, whether direct or indirect, perturbs the normal function of the cohesin complex, leading to wide-ranging consequences for cell division and genomic integrity. Indirect mechanisms of inhibition often involve the disruption of cellular pathways that, while not targeting Scc1 directly, affect the stability, localization, or function of the cohesin complex. For instance, interference with DNA repair pathways can exacerbate genomic instability, indirectly compromising cohesin's ability to maintain chromosomal cohesion. Similarly, perturbation of cell cycle regulators can lead to improper cohesin release or failure in establishing cohesion, thereby affecting Scc1's functional contribution to chromosome segregation. These indirect approaches to inhibiting Scc1 highlight the interconnected nature of cellular processes and the reliance of chromosomal cohesion on a broader network of cellular machinery. The complexity of these interactions and the critical balance required for chromosomal stability underscore the importance of Scc1 within the cell, as well as the nuanced understanding needed to elucidate the mechanisms through which its function can be modulated.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
Targets ATR kinase, crucial for DNA damage response. By inhibiting ATR, this disrupts the DNA repair process, leading to a potential compromise in cohesin loading onto chromosomes, thereby indirectly affecting Scc1's function in maintaining chromosomal cohesion. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
Inhibits CHK1/2, key enzymes in DNA damage response. This action may lead to a premature entry into mitosis, causing cohesin dysfunction. Indirectly, this could result in Scc1 failing to maintain proper chromosomal cohesion during cell division. | ||||||
2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one | 955365-80-7 | sc-483196 | 5 mg | $340.00 | 1 | |
Inhibits WEE1 kinase, affecting cell cycle arrest and DNA damage repair. This may cause cells to enter mitosis with unresolved DNA issues, indirectly leading to Scc1-mediated cohesion problems due to improper cohesin function. | ||||||
MRN-ATM Pathway Inhibitor, Mirin | 299953-00-7 | sc-203144 | 10 mg | $141.00 | 4 | |
Targets MRE11, disrupting the MRN complex critical for DNA repair. This can indirectly affect Scc1 by causing genomic instability, which challenges cohesin's role in chromosomal integrity, leading to potential cohesion deficits. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $357.00 | 10 | |
DNA-PK inhibitor, disrupts DNA double-strand break repair. This may lead to genomic instability, indirectly affecting cohesin's stability and Scc1's role in maintaining sister chromatid cohesion, as cohesin is crucial for DNA repair fidelity. | ||||||
Pyridostatin | 1085412-37-8 | sc-476422 | 10 mg | $350.00 | ||
Stabilizes G-quadruplexes, impacting replication and transcription. This could indirectly affect Scc1 by altering the genomic landscape, potentially leading to challenges in cohesin's function in chromosome cohesion and segregation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor, affects apoptosis and cell cycle regulation. By modulating transcription factors and stress responses, this could indirectly destabilize cohesin's function, affecting Scc1's role in maintaining chromosomal cohesion. | ||||||
UCN-01 | 112953-11-4 | sc-202376 | 500 µg | $251.00 | 10 | |
Inhibits protein kinase C, affecting cell cycle checkpoints. This could lead to cell cycle dysregulation, indirectly impacting cohesin's stability and thus Scc1's ability to ensure proper chromosomal segregation. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
CDK4/6 inhibitor, disrupts cell cycle progression. This may indirectly lead to Scc1 dysfunction by affecting the timing of cohesin release from chromosomes, crucial for proper chromosomal segregation and DNA repair. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
Activates AMPK, affecting cellular energy metabolism. Indirectly, this could impact Scc1 by altering cellular conditions, potentially leading to challenges in cohesin's loading and stability on chromosomes, affecting chromosomal cohesion. | ||||||