SB144 Activators
SB144 activators are a category of chemical agents that target and modulate the activity of a specific biochemical pathway in living organisms. These activators work at a molecular level to affect the function of proteins associated with the SB144 designation, which could be a receptor, enzyme, or other protein that plays a role in cellular processes. These chemical activators are designed to bind to their target with high specificity, inducing a conformational change that either increases the activity of the protein or enhances the protein's interaction with other molecules within the cell.
The design and synthesis of SB144 activators involve a deep understanding of the structure and function of the target protein. Researchers may utilize various techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, or cryo-electron microscopy to elucidate the three-dimensional structure of the target. This structural insight helps chemists to craft molecules that fit precisely into the protein's active site or a regulatory region, ensuring that the activator exerts its intended effect on the protein's activity. The specificity of these activators also minimizes the interaction with other proteins, reducing the likelihood of off-target effects that could disrupt normal cellular functions. The development of SB144 activators is a complex process, often involving iterative cycles of design, synthesis, and testing to refine the efficacy and specificity of these molecules. The interaction between an SB144 activator and its target is a critical aspect of its function, representing a key factor in the modulation of the biochemical pathways in which the target protein is involved.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels within cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate and enhance the activity of SB144 in signaling pathways where cAMP is a second messenger. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can result in the phosphorylation of SB144, thereby enhancing its activity within pathways that are modulated by PKC signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent kinases and phosphatases, potentially leading to the phosphorylation and activation of SB144 if calcium signaling is part of SB144's activation mechanism. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, increases cAMP levels, similar to Forskolin. This results in the activation of PKA, which may enhance the activity of SB144 if it is a PKA substrate or involved in cAMP-dependent pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that also activates stress-activated protein kinases (SAPKs) like JNK. Activation of JNK can lead to the phosphorylation and activation of SB144 if it plays a role in stress or JNK-related signaling pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
This bioactive lipid acts as a ligand for sphingosine-1-phosphate receptors, leading to downstream signaling that may include the activation of SB144, given that sphingolipid signaling pathways intersect with numerous cellular processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can lead to the alteration of downstream AKT signaling. Inhibition of this pathway can lead to compensatory activation of alternative pathways that may involve the activation of SB144. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a specific inhibitor of MEK1/2, leading to the inhibition of ERK signaling. This can result in a shift in cellular signaling dynamics, potentially enhancing pathways in which SB144 is active if it is associated with MAPK pathway regulation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that, similar to Ionomycin, raises intracellular calcium levels and activates calcium-dependent signaling pathways that could lead to the activation of SB144. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterase, leading to increased cAMP levels. This elevation of cAMP could enhance the activation of SB144 by stimulating cAMP-dependent signaling pathways. | ||||||