SAS-4 Inhibitors
SAS-4 inhibitors belong to a distinct chemical class renowned for their specific mode of action in cellular processes. These inhibitors primarily target a specific protein class known as the SAS-4 proteins, playing a critical role in centriole and cilia formation within cells. The SAS-4 proteins are integral components of the centrioles, essential organelles that serve as the foundation for cilia and flagella assembly. By modulating the activity of SAS-4 proteins, SAS-4 inhibitors exert a notable influence on centriole duplication and cilia biogenesis, both of which hold vital significance in various cellular functions.
The inhibitory mechanism involves direct interaction with the active site of SAS-4 proteins, thereby impeding their enzymatic or structural role in centriole assembly pathways. This specific mode of action sets SAS-4 inhibitors apart from other chemical classes, making them valuable tools in studying centriole-related cellular processes. Their distinct mechanism and specificity in targeting SAS-4 proteins make SAS-4 inhibitors essential components in the toolkit of researchers aiming to unravel the intricate mechanisms underlying centriole and cilia biology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits SAS-4 by disrupting microtubule dynamics, preventing proper spindle formation during cell division, leading to cell cycle arrest and apoptosis in cancer cells. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel binds to microtubules and enhances their stability, inhibiting their dynamics and thus preventing proper spindle assembly. This leads to cell cycle arrest and apoptosis. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine inhibits SAS-4 by binding to tubulin and preventing microtubule polymerization, disrupting mitotic spindle formation, and causing cell cycle arrest and cell death. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole inhibits SAS-4 by binding to tubulin and preventing microtubule polymerization, leading to disruption of mitotic spindle formation and cell cycle arrest. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine inhibits SAS-4 by binding to tubulin, preventing microtubule polymerization, and disrupting mitotic spindle formation, ultimately leading to cell cycle arrest. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin interferes with microtubule assembly, affecting spindle formation and preventing proper chromosome segregation, resulting in cell cycle arrest and cell death. | ||||||
Colcemid | 477-30-5 | sc-202550A sc-202550 sc-202550B sc-202550C sc-202550D sc-202550E | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg | $68.00 $162.00 $318.00 $947.00 $1893.00 $6840.00 | 7 | |
Colcemid inhibits SAS-4 by interfering with microtubule polymerization, disrupting spindle assembly, and inducing cell cycle arrest and apoptosis. | ||||||
Docetaxel | 114977-28-5 | sc-201436 sc-201436A sc-201436B | 5 mg 25 mg 250 mg | $87.00 $332.00 $1093.00 | 16 | |
Docetaxel inhibits SAS-4 by binding to and stabilizing microtubules, leading to mitotic spindle disruption, cell cycle arrest, and eventual cell death. | ||||||
Vinorelbine base | 71486-22-1 | sc-205885 sc-205885A sc-205885B sc-205885C sc-205885D | 1 mg 5 mg 25 mg 100 mg 1 g | $29.00 $81.00 $260.00 $791.00 $1977.00 | ||
Vinorelbine interferes with microtubule dynamics, disrupting spindle formation, arresting the cell cycle, and promoting apoptosis, making it effective against rapidly dividing cells. | ||||||
Estramustine | 2998-57-4 | sc-353281 sc-353281A | 100 mg 1 g | $265.00 $743.00 | ||
Estramustine hinders microtubule assembly and disrupts spindle formation, causing cell cycle arrest and apoptotic cell death, particularly in hormone-refractory prostate cancer. | ||||||