SAP 155 Inhibitors

SAP 155 inhibitors encompass a range of compounds that indirectly affect the function of SAP 155 by targeting components and processes associated with the spliceosome, where SAP 155 plays a critical role. These inhibitors primarily act by binding to or influencing the SF3b complex, a key constituent of the spliceosome, which in turn impacts SAP 155's functionality. Compounds such as Pladienolide B, E7107, and Spliceostatin A demonstrate this mechanism by binding to the SF3b complex, resulting in disrupted splicing processes and thereby indirectly modulating SAP 155's activity.

The alteration in spliceosome dynamics, brought about by these compounds, leads to a consequential effect on RNA processing, highlighting the pivotal role of SAP 155 in this essential cellular function. The diverse nature of SAP 155 inhibitors is evident in their varied mechanisms of action and molecular targets. While some, like Herboxidiene and Thailanstatin A, alter spliceosome dynamics more broadly, others, such as GEX1A and Madrasin, specifically target the SF3b complex.