SAP 145 Inhibitors

SAP 145 inhibitors, though not directly targeting SAP 145, exert their effects by modulating the spliceosome complex, of which SAP 145 is a crucial component. The primary mode of action for these compounds involves binding to or affecting other components of the SF3b complex, which in turn influences the function of SAP 145. For instance, compounds like Pladienolide B and E7107 directly bind to the SF3b complex, resulting in altered spliceosome dynamics. This alteration indirectly impedes the normal functioning of SAP 145, thereby inhibiting its role in RNA splicing. The disruption in spliceosome function can lead to widespread effects on RNA processing, reflecting the critical role of SAP 145 in this cellular process.

Another aspect of these inhibitors is their varied mechanisms of influencing the spliceosome. While some, like Herboxidiene and Thailanstatin A, primarily target the SF3b complex, others like Isoginkgetin and Silvestrol exert broader effects on splicing and translation processes.