RUNX3 Activators
RUNX3 (Runt-related transcription factor 3) activators are a class of small molecules and compounds that have the capability to modulate the activity of the RUNX3 transcription factor. RUNX3 is a critical member of the RUNX family of transcription factors, which play pivotal roles in the regulation of gene expression and cell fate determination. Specifically, RUNX3 activators are compounds that enhance the transcriptional activity of the RUNX3 protein. These activators can work through various mechanisms, including binding to specific regions of the RUNX3 protein or its associated cofactors, thereby promoting its ability to bind to target DNA sequences and activate gene expression.
The activation of RUNX3 is of significant interest in the context of cellular processes such as cell differentiation, apoptosis, and immune response regulation. RUNX3 is known to be a tumor suppressor gene in various cancers, including gastric and colorectal cancer, and its activation can promote cell cycle arrest and apoptosis in cancer cells. Additionally, RUNX3 is involved in the differentiation of various cell types, including T cells and gastric epithelial cells, making it a key player in the development and maintenance of tissues and the immune system. Therefore, RUNX3 activators have the potential to be valuable tools for studying these biological processes and may hold promise for future research aimed at understanding and manipulating cellular functions related to RUNX3 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol modulates RUNX3 expression through the Vitamin D receptor, which interacts with RUNX3 promoter regions influencing its transcriptional activity. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This compound is a DNA methyltransferase inhibitor. It reduces methylation of the RUNX3 promoter, leading to the reactivation of its expression in cells where RUNX3 is silenced by hypermethylation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can alter chromatin structure, thereby enhancing the transcription of several genes, including RUNX3, by increasing the accessibility of transcriptional machinery to the DNA. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is an isoflavone found in soy products that has been observed to upregulate RUNX3 expression potentially through its function as a tyrosine kinase inhibitor, influencing various signaling pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, a compound found in cruciferous vegetables, is reported to induce RUNX3 expression. It may exert its effect by modulating histone acetylation and DNA methylation status of the gene. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a polyphenol in turmeric, can modulate the expression of several genes including RUNX3, potentially through its anti-inflammatory and antioxidant properties, affecting various signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, the major catechin in green tea, can influence gene expression and has been implicated in the upregulation of RUNX3, possibly through epigenetic modifications that alter gene accessibility. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, found in grapes and berries, can induce RUNX3 expression. Its mechanism may involve sirtuin activation and modulation of FOXO transcription factors, which are known to interact with the RUNX3 gene. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $70.00 $290.00 $600.00 | 19 | |
CAPE, a component of propolis from bees, may enhance RUNX3 expression by inhibiting NF-kB signaling, a pathway that can epigenetically silence RUNX3 in certain cell types. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic acid, present in pomegranates and other fruits, has been shown to potentially upregulate RUNX3 expression, possibly through its effect on the PI3K/AKT pathway which is involved in cellular growth and survival signaling. | ||||||