RTP3 Inhibitors
Chemical inhibitors of RTP3 can exert their inhibitory effects through various mechanisms, targeting different signaling pathways and enzymatic activities that are crucial for the protein's function. Staurosporine, a well-known kinase inhibitor, can inhibit RTP3 by obstructing its kinase activity, which is essential for phosphorylating other proteins, a process that RTP3 may be involved in. Similarly, Bisindolylmaleimide I, by selectively inhibiting protein kinase C (PKC), can prevent the phosphorylation of RTP3 by PKC, thereby blocking its activation and subsequent signaling functions. LY294002 and Wortmannin, as PI3K inhibitors, can suppress the PI3K-Akt pathway, which, if involving RTP3, would result in the inhibition of RTP3's associated kinase activity. PD98059 and U0126 target the MEK/ERK pathway and would reduce RTP3's functional activity by inhibiting this pathway, assuming RTP3 operates downstream of it.
Further, SP600125 can inhibit RTP3 by targeting the JNK pathway, which may be necessary for RTP3's activation or signaling. SB203580 and Sorafenib can inhibit RTP3 by targeting the p38 MAP kinase and Raf kinase, respectively, which may interact with RTP3 in cellular signaling. Rapamycin inhibits the mTOR pathway, which can restrict the activity of RTP3 if it is a part of or regulated by this pathway. Gefitinib and Erlotinib, both EGFR tyrosine kinase inhibitors, can reduce RTP3 kinase activity by inhibiting the downstream signaling pathways that RTP3 might be involved in, assuming a functional relationship between RTP3 and EGFR signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, which can inhibit RTP3 by blocking its kinase activity, preventing phosphorylation events that RTP3 may mediate. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I selectively inhibits protein kinase C (PKC), a kinase that could phosphorylate RTP3, thereby inhibiting RTP3's function that depends on PKC-mediated phosphorylation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor that would inhibit downstream signaling pathways involving RTP3, thus reducing RTP3's kinase activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor, which by inhibiting the MEK/ERK pathway could reduce the functional activity of RTP3 if RTP3 were downstream of this pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which could lead to the inhibition of RTP3 if RTP3's activity is JNK-dependent. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase, potentially inhibiting RTP3 if the protein's activity is modulated through the p38 MAPK signaling axis. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that would inhibit downstream signaling pathways involving RTP3, thereby inhibiting RTP3 kinase activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that would inhibit the mTOR signaling pathway, a pathway that RTP3 may function within, thus inhibiting RTP3's activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, which by inhibiting the MEK/ERK pathway could reduce the functional activity of RTP3 if RTP3 were downstream of this pathway. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib is an EGFR tyrosine kinase inhibitor, which could inhibit downstream signaling involving RTP3, thus reducing RTP3 kinase activity if it is EGFR-dependent. | ||||||