RSP3 Inhibitors
Chemical inhibitors of RSP3 can exert their functional inhibition through various mechanisms that impact the cellular pathways RSP3 is involved in. Myricetin, for instance, targets casein kinase II (CK2), which phosphorylates a range of proteins within ciliary structures. By inhibiting CK2, myricetin reduces phosphorylation levels, leading to the functional inhibition of RSP3. Epigallocatechin gallate (EGCG) operates through the phosphoinositide 3-kinase (PI3K) pathway, which is integral to ciliary function. The inhibition of PI3K by EGCG disrupts processes essential for the activity of RSP3, thereby inhibiting its function. Similarly, daidzein and genistein, as tyrosine kinase inhibitors, obstruct the signaling necessary for various cellular functions, including those that involve ciliary movement, where RSP3 is crucial. By impeding these kinases, daidzein and genistein can suppress the functional capabilities of RSP3.
Furthermore, staurosporine, a broad-spectrum protein kinase inhibitor, can stifle the kinase activity upon which ciliary movement and function depend, thereby inhibiting RSP3 activity. Sunitinib and sorafenib, both receptor tyrosine kinase inhibitors, hinder signaling pathways that affect ciliary dynamics, indirectly leading to the inhibition of RSP3's role in those processes. GW5074, a Raf kinase inhibitor, impacts the MAPK/ERK pathway, associated with ciliary assembly and disassembly, thus affecting RSP3 functionality. Lapatinib, which targets EGFR kinases, disrupts signaling pathways that are crucial for maintaining ciliary structure and function, where RSP3 operates. Cantharidin inhibits serine/threonine phosphatases like PP1 and PP2A, whose activity is tied to ciliary function, and by inhibiting these phosphatases, RSP3's role is indirectly inhibited. ZD6474 (Vandetanib) and ibrutinib, both tyrosine kinase inhibitors, affect the signaling pathways that regulate ciliary dynamics and structure, thereby indirectly inhibiting RSP3's functional role within the ciliary architecture.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Myricetin | 529-44-2 | sc-203147 sc-203147A sc-203147B sc-203147C sc-203147D | 25 mg 100 mg 1 g 25 g 100 g | $95.00 $184.00 $255.00 $500.00 $1002.00 | 3 | |
Myricetin is a flavonoid that can inhibit casein kinase II (CK2), which is known to phosphorylate a wide variety of proteins, including those involved in ciliary function where RSP3 is localized. Inhibition of CK2 can lead to reduced phosphorylation of RSP3, resulting in its functional inhibition. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a catechin found in green tea, has been shown to inhibit the phosphoinositide 3-kinase (PI3K) pathway. Since the PI3K pathway is involved in cellular processes that include ciliary function, inhibition by EGCG can potentially reduce the activity of RSP3 within the ciliary structure. | ||||||
Daidzein | 486-66-8 | sc-24001 sc-24001A sc-24001B | 100 mg 500 mg 5 g | $25.00 $75.00 $150.00 | 32 | |
Daidzein is an isoflavone that can inhibit tyrosine kinases. Since tyrosine kinase activity is crucial for many cellular signaling pathways, including those that may involve ciliary movement where RSP3 operates, the inhibition of these kinases can impair RSP3's function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is another tyrosine kinase inhibitor that can interrupt signal transduction processes. By inhibiting this activity, genistein can disrupt the functions that rely on tyrosine phosphorylation, thereby potentially inhibiting the function of RSP3. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent, non-selective inhibitor of protein kinases. As protein kinases are crucial for many cellular processes, including ciliary movement where RSP3 is important, staurosporine can lead to the functional inhibition of RSP3 by generally blocking kinase activity. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $150.00 $920.00 | 5 | |
Sunitinib is a receptor tyrosine kinase inhibitor that can interfere with cellular signaling pathways. By inhibiting these kinases, it can impede the signal transduction that governs ciliary dynamics, potentially leading to the inhibition of RSP3's function in the cilia. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib is a kinase inhibitor that targets multiple receptors. Its inhibition of kinase activity can lead to a downstream effect on ciliary function and structure, where RSP3 plays a role, thus indirectly inhibiting RSP3 activity. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is a Raf kinase inhibitor. As Raf is a part of the MAPK/ERK pathway, which is implicated in ciliary assembly and disassembly, inhibition of Raf can hinder the proper function of RSP3 in cilia. | ||||||
Lapatinib | 231277-92-2 | sc-353658 | 100 mg | $412.00 | 32 | |
Lapatinib inhibits the epidermal growth factor receptor (EGFR) tyrosine kinases. Since EGFR signaling can influence ciliary function, lapatinib can indirectly inhibit RSP3 by disrupting the signaling pathways that maintain ciliary structure and function. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
Cantharidin is an inhibitor of serine/threonine phosphatases, including PP1 and PP2A. These phosphatases are involved in the regulation of ciliary function, and their inhibition can lead to impaired ciliary motion and structure, thus inhibiting RSP3's role within the cilia. | ||||||