RPTPα Activators
RPTPα Activators, through a spectrum of indirect mechanisms, significantly enhance the activity of RPTPα, a protein tyrosine phosphatase critical in regulating cellular signaling pathways. Compounds like Sodium Orthovanadate and PTP Inhibitor III, known as general PTP inhibitors, indirectly elevate RPTPα activity by inhibiting a range of other phosphatases. This inhibition creates a compensatory effect, leading to an upregulation of RPTPα activity to maintain the balance in cellular phosphatase activities. Similarly, oxidative agents like Hydrogen Peroxide can modulate the redox state of cells, resulting in the transient inactivation of certain PTPs, thereby indirectly increasing the relative activity of RPTPα. Zinc, by selectively inhibiting some PTPs, also contribute to this compensatory increase in RPTPα activity, essential for the proper functioning of signal transduction pathways.
Furthermore, environmental and chemical agents such as Bisphenol A, DTT, Phenylarsine Oxide, and Sanguinarium influence RPTPα activity by altering the signaling landscape within cells. Bisphenol A, by interfering with kinase and phosphatase signaling pathways, can lead to changes in RPTPα function. DTT, through its reducing properties, affects the redox balance, potentially enhancing RPTPα's activity relative to other PTPs. Okadaic Acid and Calyculin A, as inhibitors of protein serine/threonine phosphatases, shift the equilibrium towards increased RPTPα activity in phosphorylation-dependent signaling processes. NSC 87877, by specifically inhibiting SHP2 and PTP1B, may lead to a compensatory increase in RPTPα activity. These diverse mechanisms collectively underscore the complex regulatory network influencing RPTPα activity, highlighting its crucial role in mediating cellular responses and maintaining signaling fidelity in various physiological contexts.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium Orthovanadate, a general PTP inhibitor, indirectly enhances RPTPα activity by inhibiting other PTPs. This inhibition may lead to a compensatory increase in RPTPα activity, thereby influencing its role in cell signaling pathways. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen Peroxide, as an oxidative agent, can indirectly enhance RPTPα activity. Hydrogen Peroxide modulates the redox state of cells, potentially leading to a transient inactivation of other PTPs and a relative increase in RPTPα activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc can indirectly enhance RPTPα activity. Zinc is known to inhibit certain PTPs, and its presence may shift the phosphatase equilibrium towards increased RPTPα activity in signal transduction. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A, an environmental estrogen, can indirectly influence RPTPα activity. It may interfere with kinase and phosphatase signaling pathways, potentially leading to altered RPTPα function in cells. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid, a potent inhibitor of protein serine/threonine phosphatases, indirectly influences RPTPα activity. By inhibiting these phosphatases, it may shift the balance towards increased RPTPα activity in signal transduction pathways. | ||||||
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $41.00 | 4 | |
Phenylarsine Oxide, an organoarsenic compound, can indirectly enhance RPTPα activity. It binds to vicinal thiols, potentially affecting the activity of other PTPs and leading to increased RPTPα activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A, a specific inhibitor of protein serine/threonine phosphatases, can indirectly enhance RPTPα activity. By inhibiting these phosphatases, it may indirectly increase RPTPα's role in phosphorylation-dependent signaling. | ||||||
NSC 87877 | 56990-57-9 | sc-204139 | 50 mg | $137.00 | 12 | |
NSC 87877, a dual SHP2/PTP1B inhibitor, can indirectly enhance RPTPα activity. By specifically inhibiting SHP2 and PTP1B, it may lead to a compensatory increase in RPTPα activity in signaling pathways. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $89.00 $279.00 | 6 | |
Cantharidin, an inhibitor of serine/threonine phosphatases, indirectly influences RPTPα activity. This influence may result in a shift towards increased RPTPα activity in cellular signaling processes. | ||||||
Sanguinarium | 2447-54-3 | sc-473396 | 10 mg | $220.00 | ||
Sanguinarium, a benzophenanthridine alkaloid, indirectly enhances RPTPα activity. It inhibits a broad range of PTPs, potentially leading to a relative increase in RPTPα activity within the cell. | ||||||