Rpp25 Inhibitors
Chemical inhibitors of Rpp25 can impede its function in RNA processing pathways by various means. Alsterpaullone, a cyclin-dependent kinase inhibitor, can hinder the phosphorylation that is necessary for the activation of proteins within the RNA processing machinery in which Rpp25 operates. Similarly, roscovitine targets cyclin-dependent kinases to prevent essential phosphorylation processes, therefore likely inhibiting Rpp25's role in RNA maturation. 5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) specifically inhibits RNA Polymerase II, which is responsible for the transcription of mRNA precursors that are substrates for Rpp25, leading to a decrease in Rpp25's functional activity due to reduced substrate availability. Flavopiridol, another broad kinase inhibitor, disrupts the phosphorylation of RNA polymerase II and related factors, likely impairing Rpp25's involvement in RNA processing.
Triptolide and α-Amanitin are potent inhibitors of RNA Polymerase II, which directly leads to reduced RNA synthesis and thus a decrease in RNA precursors that require processing by Rpp25. Actinomycin D, by intercalating into DNA, prevents RNA transcription that includes RNA processed by Rpp25, thereby inhibiting the protein's primary function. Distamycin A binds to the DNA minor groove, which can impede transcription factor binding and consequent transcription, reducing the RNA available for Rpp25 processing. Mitoxantrone, through DNA intercalation and Topoisomerase II inhibition, can lead to decreased synthesis of RNA, indirectly inhibiting Rpp25 by limiting its substrate. Cordycepin, an adenosine analog, terminates RNA synthesis upon incorporation, thereby restricting RNA levels and inhibiting Rpp25's RNA processing activities. Homoharringtonine acts by inhibiting protein synthesis at the translation elongation step, which can indirectly inhibit Rpp25 by affecting the efficiency of cellular RNA processing. Finally, tautomycin, as an inhibitor of protein phosphatases PP1 and PP2A, can lead to an altered phosphorylation state of proteins involved in RNA processing, potentially inhibiting the function of Rpp25 within this pathway.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
Alsterpaullone is a cyclin-dependent kinase inhibitor that can inhibit the phosphorylation process crucial for the activation of certain proteins. Rpp25, being part of the RNA processing pathway, could be functionally inhibited as phosphorylation is critical for RNA processing machinery. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine inhibits cyclin-dependent kinases. By inhibiting these kinases, the chemical prevents the phosphorylation of proteins necessary for RNA processing, potentially inhibiting Rpp25's role in RNA maturation. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB acts as an inhibitor of RNA Polymerase II, which is required for the synthesis of mRNA precursors that Rpp25 processes. By inhibiting RNA Polymerase II, DRB can impede the production of substrates necessary for Rpp25 function. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol is a broad kinase inhibitor, particularly of cyclin-dependent kinases involved in the phosphorylation of RNA polymerase II and related factors. This inhibition would disrupt the processing of RNA, a pathway in which Rpp25 is involved. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide inhibits the activity of RNA Polymerase II, leading to a reduction in RNA synthesis. As Rpp25 is involved in RNA processing, triptolide's action would result in less substrate availability for Rpp25, functionally inhibiting its role. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin is a potent inhibitor of RNA Polymerase II. By binding to RNA polymerase II, it prevents the transcription of mRNA, thereby inhibiting the processing of RNA precursors where Rpp25 is crucial. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D intercalates into DNA and prevents the transcription of RNA by RNA Polymerase, which includes RNA that would be processed by Rpp25. This intercalation inhibits the primary function of Rpp25. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $285.00 | 8 | |
Mitoxantrone intercalates DNA and inhibits Topoisomerase II, which can lead to decreased RNA synthesis. Reduced RNA synthesis would indirectly inhibit Rpp25 by decreasing its RNA substrate. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Cordycepin is an adenosine analog that terminates RNA synthesis upon incorporation, effectively reducing RNA levels and inhibiting the RNA processing activities of Rpp25. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $52.00 $125.00 $182.00 | 11 | |
Homoharringtonine inhibits protein synthesis at the translation elongation step. Although Rpp25 is involved in RNA processing, the reduction in protein synthesis can indirectly inhibit Rpp25 by affecting overall cellular RNA processing efficiency. | ||||||