RNF113B Inhibitors

RNF113B is a member of the ring finger protein family of E3 ubiquitin ligases, which are characterized by the presence of a zinc-finger domain that binds two zinc ions. The defining feature of RNF proteins is their role in mediating the transfer of ubiquitin to specific substrate proteins, a process that typically tags these substrates for proteasomal degradation but can also alter their activity, location, or interactions. The ubiquitination process is crucial for numerous cellular processes, including cell cycle regulation, DNA repair, and signal transduction.

The RNF113B gene encodes the RNF113B protein, which exhibits a distinctive pattern of expression and biological function. As an E3 ubiquitin ligase, RNF113B is involved in the post-translational modification of proteins through the ubiquitin-proteasome system. This system maintains cellular homeostasis by controlling the degradation of misfolded, damaged, or unnecessary proteins.The specific substrates and molecular mechanisms of action for RNF113B are not as well characterized as those of some other members of the RNF family. However, like other E3 ligases, RNF113B is believed to participate in the intricate regulation of cellular processes through its enzymatic activity. The ubiquitination of proteins by RNF113B could impact various cellular pathways, such as the stress response, DNA damage repair, or transcriptional regulation, by affecting the stability and function of key regulatory proteins.