RNF113B Antibody (A-8): sc-518257

RNF113B Antibody (A-8) is a mouse monoclonal IgG1 kappa light chain antibody specific for an epitope mapping between amino acids 60-88 of RNF113B of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-RNF113B antibody (A-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. RNF113B, also known as ring finger protein 113B, zinc finger protein 183-like 1 (ZNF183L1), or RNF161, is a 322 amino acid protein characterized by the presence of a RING-type zinc finger motif, which is crucial for its role in the ubiquitination pathway, a key mechanism for protein degradation and regulation within the cell. RNF113B′s ability to facilitate the attachment of ubiquitin molecules to target proteins is vital for maintaining cellular homeostasis and regulating various biological processes, including cell cycle progression and response to stress. The gene encoding RNF113B is located on human chromosome 13, a region that is significant not only for its dense gene content, including critical genes like BRCA2 and RB1, but also for its association with genetic disorders such as trisomy 13, which can lead to severe developmental issues. The study of RNF113B and its interactions is essential for understanding the complexities of cellular regulation and the implications of its dysfunction in various diseases. These characteristics highlight RNF113B (A-8) antibody′s utility as a crucial tool for studying the role of RNF113B in ubiquitination, cellular regulation, and disease-associated processes.

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RNF113B Antibody (A-8) References:

1. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.  |  Lorick, KL., et al. 1999. Proc Natl Acad Sci U S A. 96: 11364-9. PMID: 10500182
2. The HIV-1 nucleocapsid zinc finger protein as a target of antiretroviral therapy.  |  Musah, RA. 2004. Curr Top Med Chem. 4: 1605-22. PMID: 15579099
3. Non-disjunction of chromosome 13.  |  Bugge, M., et al. 2007. Hum Mol Genet. 16: 2004-10. PMID: 17584770
4. Variable expressivity in Patau syndrome is not all related to trisomy 13 mosaicism.  |  Hsu, HF. and Hou, JW. 2007. Am J Med Genet A. 143A: 1739-48. PMID: 17603803
5. The origin of trisomy 13.  |  Hall, HE., et al. 2007. Am J Med Genet A. 143A: 2242-8. PMID: 17853475
6. Primate and rodent specific intron gains and the origin of retrogenes with splice variants.  |  Szcześniak, MW., et al. 2011. Mol Biol Evol. 28: 33-7. PMID: 20889727
7. Novel mutation and three other sequence variants segregating with phenotype at keratoconus 13q32 susceptibility locus.  |  Czugala, M., et al. 2012. Eur J Hum Genet. 20: 389-97. PMID: 22045297
8. Snail/Gfi-1 (SNAG) family zinc finger proteins in transcription regulation, chromatin dynamics, cell signaling, development, and disease.  |  Chiang, C. and Ayyanathan, K. 2013. Cytokine Growth Factor Rev. 24: 123-31. PMID: 23102646
9. A bioinformatics analysis of zinc finger protein family reveals potential oncogenic biomarkers in breast cancer.  |  An, G., et al. 2022. Gene. 828: 146471. PMID: 35378249
10. ZIF-1-mediated degradation of zinc finger proteins in the Caenorhabditis elegans germ line.  |  Schwartz, AZA., et al. 2023. Genetics. 225: PMID: 37647858
11. The RING finger. A novel protein sequence motif related to the zinc finger.  |  Freemont, PS. 1993. Ann N Y Acad Sci. 684: 174-92. PMID: 8317827
12. The RING finger domain: a recent example of a sequence-structure family.  |  Borden, KL. and Freemont, PS. 1996. Curr Opin Struct Biol. 6: 395-401. PMID: 8804826

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RNF113B Antibody (A-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-RNF113B Antibody (A-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RNF113B Antibody (A-8) Specifications

Alternate Product Name: RNF113B

Product Clone Name: A-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 60-88

Epitope Target: RNF113B

Epitope Species: human

Product Reactivity/Detection: RNF113B

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for RNF113B Antibody (A-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin