Date published: 2025-12-16

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RNA Polymerase CRISPR Plasmids

Santa Cruz Biotechnology, Inc. offers a broad range of gene editing products including CRISPR/Cas9 Knockout and CRISPR Double Nickase plasmids for gene silencing. RNA Polymerase gene silencers are available as RNA Polymerase CRISPR/Cas9 Knockout plasmids and RNA Polymerase Double Nickase Plasmids. RNA Polymerase CRISPR/dCas9 Activation Plasmids and CRISPR Lenti Activation Systems for gene activation are also available. Gene silencers and activators are useful for gene studies in combination with antibodies used for protein detection.

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RNA Polymerase CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Pol II CRISPR/Cas9 KO Plasmid (h2)

sc-400053-KO-2hGene KnockoutGFP0
(0)

Pol II Double Nickase Plasmid (h)

sc-400053-NIChGene KnockoutPuromycin0
(0)

Pol II Double Nickase Plasmid (h2)

sc-400053-NIC-2hGene KnockoutPuromycin0
(0)

Pol II CRISPR/Cas9 KO Plasmid (m)

sc-422732mGene KnockoutGFP0
(0)

Pol II HDR Plasmid (m)

sc-422732-HDRmHomology Directed RepairPuromycin0
(0)

Pol II Double Nickase Plasmid (m)

sc-422732-NICmGene KnockoutPuromycin0
(0)

Pol II Double Nickase Plasmid (m2)

sc-422732-NIC-2mGene KnockoutPuromycin0
(0)

Pol II-H CRISPR/Cas9 KO Plasmid (m)

sc-434173mGene KnockoutGFP0
(0)

Pol II-H HDR Plasmid (m)

sc-434173-HDRmHomology Directed RepairPuromycin0
(0)

Pol II-H Double Nickase Plasmid (m)

sc-434173-NICmGene KnockoutPuromycin0
(0)

Pol II-H Double Nickase Plasmid (m2)

sc-434173-NIC-2mGene KnockoutPuromycin0
(0)

Pol II RPB6 CRISPR/Cas9 KO Plasmid (h)

sc-406479hGene KnockoutGFP0
(0)

Pol II RPB6 HDR Plasmid (h)

sc-406479-HDRhHomology Directed RepairPuromycin0
(0)

Pol II RPB6 Double Nickase Plasmid (h)

sc-406479-NIChGene KnockoutPuromycin0
(0)

Pol II RPB6 Double Nickase Plasmid (h2)

sc-406479-NIC-2hGene KnockoutPuromycin0
(0)

Pol II RPB6 CRISPR/Cas9 KO Plasmid (m)

sc-427551mGene KnockoutGFP0
(0)

Pol II RPB6 HDR Plasmid (m)

sc-427551-HDRmHomology Directed RepairPuromycin0
(0)

Pol II RPB6 Double Nickase Plasmid (m)

sc-427551-NICmGene KnockoutPuromycin0
(0)

Pol II RPB6 Double Nickase Plasmid (m2)

sc-427551-NIC-2mGene KnockoutPuromycin0
(0)

Pol I/II/III RPB8 CRISPR/Cas9 KO Plasmid (h)

sc-406520hGene KnockoutGFP0
(0)

Pol I/II/III RPB8 Double Nickase Plasmid (h)

sc-406520-NIChGene KnockoutPuromycin0
(0)

Pol I/II/III RPB8 Double Nickase Plasmid (h2)

sc-406520-NIC-2hGene KnockoutPuromycin0
(0)

RPA16 CRISPR/Cas9 KO Plasmid (h)

sc-416274hGene KnockoutGFP0
(0)

RPA16 HDR Plasmid (h)

sc-416274-HDRhHomology Directed RepairPuromycin0
(0)

RPA16 Double Nickase Plasmid (h)

sc-416274-NIChGene KnockoutPuromycin0
(0)

RPA16 Double Nickase Plasmid (h2)

sc-416274-NIC-2hGene KnockoutPuromycin0
(0)

RPA16 CRISPR/Cas9 KO Plasmid (m)

sc-422730mGene KnockoutGFP0
(0)

RPA16 HDR Plasmid (m)

sc-422730-HDRmHomology Directed RepairPuromycin0
(0)

RPA16 Double Nickase Plasmid (m)

sc-422730-NICmGene KnockoutPuromycin0
(0)

RPA16 Double Nickase Plasmid (m2)

sc-422730-NIC-2mGene KnockoutPuromycin0
(0)

Pol III RPC32 CRISPR/Cas9 KO Plasmid (h)

sc-417072hGene KnockoutGFP
1
(0)

Pol III RPC32 HDR Plasmid (h)

sc-417072-HDRhHomology Directed RepairPuromycin
1
(0)

Pol III RPC32 Double Nickase Plasmid (h)

sc-417072-NIChGene KnockoutPuromycin
1
(0)

Pol III RPC32 Double Nickase Plasmid (h2)

sc-417072-NIC-2hGene KnockoutPuromycin
1
(0)

Pol III RPC32 CRISPR/Cas9 KO Plasmid (m)

sc-426592mGene KnockoutGFP0
(0)

Pol III RPC32 HDR Plasmid (m)

sc-426592-HDRmHomology Directed RepairPuromycin0
(0)

Pol III RPC32 Double Nickase Plasmid (m)

sc-426592-NICmGene KnockoutPuromycin0
(0)

Pol III RPC32 Double Nickase Plasmid (m2)

sc-426592-NIC-2mGene KnockoutPuromycin0
(0)

Pol III RPC39 CRISPR/Cas9 KO Plasmid (h)

sc-409791hGene KnockoutGFP0
(0)

Pol III RPC39 HDR Plasmid (h)

sc-409791-HDRhHomology Directed RepairPuromycin0
(0)

Pol III RPC39 Double Nickase Plasmid (h)

sc-409791-NIChGene KnockoutPuromycin0
(0)

Pol III RPC39 Double Nickase Plasmid (h2)

sc-409791-NIC-2hGene KnockoutPuromycin0
(0)

Pol III RPC39 CRISPR/Cas9 KO Plasmid (m)

sc-427698mGene KnockoutGFP0
(0)

Pol III RPC39 HDR Plasmid (m)

sc-427698-HDRmHomology Directed RepairPuromycin0
(0)

Pol III RPC39 Double Nickase Plasmid (m)

sc-427698-NICmGene KnockoutPuromycin0
(0)

Pol III RPC39 Double Nickase Plasmid (m2)

sc-427698-NIC-2mGene KnockoutPuromycin0
(0)

RPA40 CRISPR/Cas9 KO Plasmid (h)

sc-404594hGene KnockoutGFP0
(0)

RPA40 CRISPR/Cas9 KO Plasmid (h2)

sc-404594-KO-2hGene KnockoutGFP0
(0)

RPA40 HDR Plasmid (h2)

sc-404594-HDR-2hHomology Directed RepairPuromycin0
(0)

RPA40 Double Nickase Plasmid (h)

sc-404594-NIChGene KnockoutPuromycin0
(0)

RPA40 Double Nickase Plasmid (h2)

sc-404594-NIC-2hGene KnockoutPuromycin0
(0)

RPA40 CRISPR/Cas9 KO Plasmid (m)

sc-422728mGene KnockoutGFP0
(0)

RPA40 HDR Plasmid (m)

sc-422728-HDRmHomology Directed RepairPuromycin0
(0)

RPA40 Double Nickase Plasmid (m)

sc-422728-NICmGene KnockoutPuromycin0
(0)

RPA40 Double Nickase Plasmid (m2)

sc-422728-NIC-2mGene KnockoutPuromycin0
(0)

Pol III RPC62 CRISPR/Cas9 KO Plasmid (h)

sc-411493hGene KnockoutGFP0
(0)

Pol III RPC62 HDR Plasmid (h)

sc-411493-HDRhHomology Directed RepairPuromycin0
(0)

Pol III RPC62 Double Nickase Plasmid (h)

sc-411493-NIChGene KnockoutPuromycin0
(0)

Pol III RPC62 Double Nickase Plasmid (h2)

sc-411493-NIC-2hGene KnockoutPuromycin0
(0)

Pol III RPC62 CRISPR/Cas9 KO Plasmid (m)

sc-428877mGene KnockoutGFP0
(0)

Pol III RPC62 HDR Plasmid (m)

sc-428877-HDRmHomology Directed RepairPuromycin0
(0)

Pol III RPC62 Double Nickase Plasmid (m)

sc-428877-NICmGene KnockoutPuromycin0
(0)

Pol III RPC62 Double Nickase Plasmid (m2)

sc-428877-NIC-2mGene KnockoutPuromycin0
(0)

RPA135 CRISPR/Cas9 KO Plasmid (h)

sc-402818hGene KnockoutGFP0
(0)

RPA135 CRISPR/Cas9 KO Plasmid (h2)

sc-402818-KO-2hGene KnockoutGFP0
(0)

RPA135 HDR Plasmid (h2)

sc-402818-HDR-2hHomology Directed RepairPuromycin0
(0)

RPA135 Double Nickase Plasmid (h)

sc-402818-NIChGene KnockoutPuromycin0
(0)

RPA135 Double Nickase Plasmid (h2)

sc-402818-NIC-2hGene KnockoutPuromycin0
(0)

RPA135 CRISPR/Cas9 KO Plasmid (m)

sc-422729mGene KnockoutGFP0
(0)

RPA135 HDR Plasmid (m)

sc-422729-HDRmHomology Directed RepairPuromycin0
(0)

RPA135 Double Nickase Plasmid (m)

sc-422729-NICmGene KnockoutPuromycin0
(0)

RPA135 Double Nickase Plasmid (m2)

sc-422729-NIC-2mGene KnockoutPuromycin0
(0)

RPA194 CRISPR/Cas9 KO Plasmid (h)

sc-400816hGene KnockoutGFP0
(0)

RPA194 HDR Plasmid (h)

sc-400816-HDRhHomology Directed RepairPuromycin0
(0)

RPA194 Double Nickase Plasmid (h)

sc-400816-NIChGene KnockoutPuromycin0
(0)

RPA194 Double Nickase Plasmid (h2)

sc-400816-NIC-2hGene KnockoutPuromycin0
(0)

RPA194 CRISPR/Cas9 KO Plasmid (m)

sc-422731mGene KnockoutGFP0
(0)

RPA194 HDR Plasmid (m)

sc-422731-HDRmHomology Directed RepairPuromycin0
(0)

RPA194 Double Nickase Plasmid (m)

sc-422731-NICmGene KnockoutPuromycin0
(0)

RPA194 Double Nickase Plasmid (m2)

sc-422731-NIC-2mGene KnockoutPuromycin0
(0)

RNA Polymerase CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Pol II CRISPR Activation Plasmid (h)

sc-400053-ACThGene ActivationPuro, Blast, Hygro0
(0)

Pol II CRISPR Activation Plasmid (h2)

sc-400053-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

Pol II Lentiviral Activation Particles (h)

sc-400053-LAChGene ActivationPuro, Blast, Hygro0
(0)

Pol II Lentiviral Activation Particles (h2)

sc-400053-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

Pol II CRISPR Activation Plasmid (m)

sc-422732-ACTmGene ActivationPuro, Blast, Hygro0
(0)

Pol II CRISPR Activation Plasmid (m2)

sc-422732-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

Pol II Lentiviral Activation Particles (m)

sc-422732-LACmGene ActivationPuro, Blast, Hygro0
(0)

Pol II Lentiviral Activation Particles (m2)

sc-422732-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

Pol II-H CRISPR Activation Plasmid (m)

sc-434173-ACTmGene ActivationPuro, Blast, Hygro0
(0)

Pol II-H CRISPR Activation Plasmid (m2)

sc-434173-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

Pol II-H Lentiviral Activation Particles (m)

sc-434173-LACmGene ActivationPuro, Blast, Hygro0
(0)

Pol II-H Lentiviral Activation Particles (m2)

sc-434173-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

Pol II RPB6 CRISPR Activation Plasmid (h)

sc-406479-ACThGene ActivationPuro, Blast, Hygro0
(0)

Pol II RPB6 CRISPR Activation Plasmid (h2)

sc-406479-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

Pol II RPB6 Lentiviral Activation Particles (h)

sc-406479-LAChGene ActivationPuro, Blast, Hygro0
(0)

Pol II RPB6 Lentiviral Activation Particles (h2)

sc-406479-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

Pol II RPB6 CRISPR Activation Plasmid (m)

sc-427551-ACTmGene ActivationPuro, Blast, Hygro0
(0)

Pol II RPB6 CRISPR Activation Plasmid (m2)

sc-427551-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

Pol II RPB6 Lentiviral Activation Particles (m)

sc-427551-LACmGene ActivationPuro, Blast, Hygro0
(0)

Pol II RPB6 Lentiviral Activation Particles (m2)

sc-427551-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

Pol I/II/III RPB8 CRISPR Activation Plasmid (h)

sc-406520-ACThGene ActivationPuro, Blast, Hygro0
(0)

Pol I/II/III RPB8 CRISPR Activation Plasmid (h2)

sc-406520-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

Pol I/II/III RPB8 Lentiviral Activation Particles (h)

sc-406520-LAChGene ActivationPuro, Blast, Hygro0
(0)

Pol I/II/III RPB8 Lentiviral Activation Particles (h2)

sc-406520-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

RPA16 CRISPR Activation Plasmid (h)

sc-416274-ACThGene ActivationPuro, Blast, Hygro0
(0)

RPA16 CRISPR Activation Plasmid (h2)

sc-416274-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

RPA16 Lentiviral Activation Particles (h)

sc-416274-LAChGene ActivationPuro, Blast, Hygro0
(0)

RPA16 Lentiviral Activation Particles (h2)

sc-416274-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

RPA16 CRISPR Activation Plasmid (m)

sc-422730-ACTmGene ActivationPuro, Blast, Hygro0
(0)

RPA16 CRISPR Activation Plasmid (m2)

sc-422730-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

RPA16 Lentiviral Activation Particles (m)

sc-422730-LACmGene ActivationPuro, Blast, Hygro0
(0)

RPA16 Lentiviral Activation Particles (m2)

sc-422730-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC32 CRISPR Activation Plasmid (h)

sc-417072-ACThGene ActivationPuro, Blast, Hygro
1
(0)

Pol III RPC32 CRISPR Activation Plasmid (h2)

sc-417072-ACT-2hGene ActivationPuro, Blast, Hygro
1
(0)

Pol III RPC32 Lentiviral Activation Particles (h)

sc-417072-LAChGene ActivationPuro, Blast, Hygro
1
(0)

Pol III RPC32 Lentiviral Activation Particles (h2)

sc-417072-LAC-2hGene ActivationPuro, Blast, Hygro
1
(0)

Pol III RPC32 CRISPR Activation Plasmid (m)

sc-426592-ACTmGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC32 CRISPR Activation Plasmid (m2)

sc-426592-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC32 Lentiviral Activation Particles (m)

sc-426592-LACmGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC32 Lentiviral Activation Particles (m2)

sc-426592-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC39 CRISPR Activation Plasmid (h)

sc-409791-ACThGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC39 CRISPR Activation Plasmid (h2)

sc-409791-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC39 Lentiviral Activation Particles (h)

sc-409791-LAChGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC39 Lentiviral Activation Particles (h2)

sc-409791-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC39 CRISPR Activation Plasmid (m)

sc-427698-ACTmGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC39 CRISPR Activation Plasmid (m2)

sc-427698-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC39 Lentiviral Activation Particles (m)

sc-427698-LACmGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC39 Lentiviral Activation Particles (m2)

sc-427698-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

RPA40 CRISPR Activation Plasmid (h)

sc-404594-ACThGene ActivationPuro, Blast, Hygro0
(0)

RPA40 CRISPR Activation Plasmid (h2)

sc-404594-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

RPA40 Lentiviral Activation Particles (h)

sc-404594-LAChGene ActivationPuro, Blast, Hygro0
(0)

RPA40 Lentiviral Activation Particles (h2)

sc-404594-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

RPA40 CRISPR Activation Plasmid (m)

sc-422728-ACTmGene ActivationPuro, Blast, Hygro0
(0)

RPA40 CRISPR Activation Plasmid (m2)

sc-422728-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

RPA40 Lentiviral Activation Particles (m)

sc-422728-LACmGene ActivationPuro, Blast, Hygro0
(0)

RPA40 Lentiviral Activation Particles (m2)

sc-422728-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC62 CRISPR Activation Plasmid (h)

sc-411493-ACThGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC62 CRISPR Activation Plasmid (h2)

sc-411493-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC62 Lentiviral Activation Particles (h)

sc-411493-LAChGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC62 Lentiviral Activation Particles (h2)

sc-411493-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC62 CRISPR Activation Plasmid (m)

sc-428877-ACTmGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC62 CRISPR Activation Plasmid (m2)

sc-428877-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC62 Lentiviral Activation Particles (m)

sc-428877-LACmGene ActivationPuro, Blast, Hygro0
(0)

Pol III RPC62 Lentiviral Activation Particles (m2)

sc-428877-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

RPA135 CRISPR Activation Plasmid (h)

sc-402818-ACThGene ActivationPuro, Blast, Hygro0
(0)

RPA135 CRISPR Activation Plasmid (h2)

sc-402818-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

RPA135 Lentiviral Activation Particles (h)

sc-402818-LAChGene ActivationPuro, Blast, Hygro0
(0)

RPA135 Lentiviral Activation Particles (h2)

sc-402818-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

RPA135 CRISPR Activation Plasmid (m)

sc-422729-ACTmGene ActivationPuro, Blast, Hygro0
(0)

RPA135 CRISPR Activation Plasmid (m2)

sc-422729-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

RPA135 Lentiviral Activation Particles (m)

sc-422729-LACmGene ActivationPuro, Blast, Hygro0
(0)

RPA135 Lentiviral Activation Particles (m2)

sc-422729-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

RPA194 CRISPR Activation Plasmid (h)

sc-400816-ACThGene ActivationPuro, Blast, Hygro0
(0)

RPA194 CRISPR Activation Plasmid (h2)

sc-400816-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

RPA194 Lentiviral Activation Particles (h)

sc-400816-LAChGene ActivationPuro, Blast, Hygro0
(0)

RPA194 Lentiviral Activation Particles (h2)

sc-400816-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

RPA194 CRISPR Activation Plasmid (m)

sc-422731-ACTmGene ActivationPuro, Blast, Hygro0
(0)

RPA194 CRISPR Activation Plasmid (m2)

sc-422731-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

RPA194 Lentiviral Activation Particles (m)

sc-422731-LACmGene ActivationPuro, Blast, Hygro0
(0)

RPA194 Lentiviral Activation Particles (m2)

sc-422731-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)