Ribosomal Protein L38 Inhibitors
Ribosomal Protein L38 inhibitors like Cycloheximide and anisomycin disrupt the elongation phase of protein synthesis, which could alter the dynamics of ribosomal proteins, including RPL38. Antibiotics such as chloramphenicol, tetracycline, erythromycin, and fusidic acid inhibit bacterial protein synthesis by binding to ribosomal subunits, implying that similar mechanisms could influence RPL38 function in eukaryotic cells.
Toxins like ricin and α-sarcin cleave ribosomal RNA, destabilizing the ribosome and potentially affecting RPL38. Compounds such as puromycin mimic aminoacyl-tRNA, causing premature chain termination and suggesting a disruption in the ribosome's integrity where RPL38 is seated. Sparsomycin and pactamycin inhibit peptide bond formation and initiation of protein synthesis, respectively, showcasing mechanisms that can indirectly alter RPL38 function by impeding ribosomal assembly and activity. Oligomycin A impacts ATP synthesis; by reducing the energy available for protein synthesis, it can indirectly influence RPL38's incorporation into the ribosome. These inhibitors highlight the complexity of the ribosome and the interdependence of its components.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Inhibits eukaryotic protein synthesis by interfering with the translocation step in protein synthesis, thus potentially affecting the function of RPL38 as part of the ribosome. | ||||||
α-Sarcin | 86243-64-3 | sc-204427 | 1 mg | $316.00 | 6 | |
Cleaves a specific phosphodiester bond within the ribosomal RNA of the large ribosomal subunit, disrupting the function of the ribosome and possibly impacting RPL38 indirectly. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $40.00 $210.00 $816.00 $65.00 | 394 | |
Causes premature chain termination during translation by acting as an analog of aminoacyl-tRNA, potentially impacting RPL38 function within the ribosome. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
Binds to the 50S ribosomal subunit and inhibits bacterial protein synthesis, potentially affecting the overall ribosome structure and indirectly the function of RPL38 in eukaryotic ribosomes. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $62.00 $92.00 $265.00 $409.00 $622.00 | 6 | |
Interacts with the 30S ribosomal subunit and inhibits the binding of aminoacyl-tRNA to the A site of the ribosome, which could indirectly affect RPL38's role in the larger ribosomal complex. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $56.00 $240.00 $815.00 $1305.00 | 4 | |
Binds to the 50S subunit of the bacterial ribosome, inhibiting protein synthesis. This may have indirect effects on the structure and function of eukaryotic ribosomes, thereby influencing RPL38 function. | ||||||
Fusidic acid | 6990-06-3 | sc-215065 | 1 g | $292.00 | ||
Blocks the turnover of elongation factor G (EF-G) from the ribosome, indirectly affecting ribosomal activity and potentially the function of RPL38. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Inhibits peptide bond formation by binding to the 60S ribosomal subunit. This action can indirectly influence RPL38 activity by disrupting normal ribosome function. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
Targets mitochondrial ATP synthase, affecting cellular energy production. Indirectly, this can influence the synthesis of ribosomal proteins like RPL38 by altering the energy-dependent processes of protein synthesis. | ||||||