Rho J Activators
Rho J Activators belong to a class of chemical compounds that play a pivotal role in cellular signaling pathways and are primarily known for their influence on the regulation of cell morphology and cytoskeletal dynamics. These activators are characterized by their ability to modulate the activity of Rho GTPases, a family of small G proteins that act as molecular switches, controlling various cellular processes such as cell migration, adhesion, and shape changes. Rho GTPases, including RhoA, RhoB, and RhoC, are key regulators of the actin cytoskeleton, and their activation is essential for various physiological processes.
Rho J Activators function by promoting the activation of Rho GTPases, leading to downstream signaling events that ultimately affect the organization of the actin cytoskeleton. This class of compounds can induce a shift in cellular morphology, often leading to the formation of stress fibers, which are bundles of actin filaments. These changes in cell shape and cytoskeletal rearrangements can have significant implications in various cellular processes, including cell motility, adhesion, and tissue development. Moreover, the modulation of Rho GTPase activity by Rho J Activators has been of interest in the fields of cell biology and research, as it provides a valuable tool for studying the underlying mechanisms of cell migration and cytoskeletal dynamics. Understanding these processes is crucial for unraveling fundamental cellular functions and their roles in health and disease.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly increases intracellular cAMP levels, which activates protein kinase A (PKA). PKA can phosphorylate various substrates that modulate the actin cytoskeleton dynamics, leading to the functional activation of RhoJ which is directly involved in cytoskeletal organization and cell migration. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 selectively inhibits ROCK, a Rho-associated coiled-coil containing protein kinase. Inhibition of ROCK can shift the balance toward the activation of other Rho GTPases, potentially increasing the activity of RhoJ in cytoskeletal rearrangements. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which can phosphorylate various targets that influence the actin cytoskeleton. PKC activation has been shown to enhance RhoJ activation, impacting cell shape and motility. | ||||||
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $465.00 | ||
GTPγS is a non-hydrolyzable analog of GTP and acts as an activator of GTPases like RhoJ. Binding of GTPγS to RhoJ leads to its persistent activation, promoting changes in cytoskeletal organization and cell motility. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
LPA works through G-protein coupled receptors to activate Rho GTPases. LPA receptor activation leads to the activation of RhoJ, which influences cytoskeletal dynamics and plays a role in cell migration. | ||||||
Calpeptin | 117591-20-5 | sc-202516 sc-202516A | 10 mg 50 mg | $121.00 $456.00 | 28 | |
Calpeptin inhibits calpain, a protease that can modulate the activity of Rho proteins by cleaving Rho GTPase-activating proteins (GAPs). Inhibition of calpain may thus enhance the activity of RhoJ by preventing the inactivation of its active GTP-bound form. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P binds to its G-protein coupled receptors, which can activate Rho family GTPases. S1P receptor activation leads to the functional enhancement of RhoJ, impacting actin cytoskeletal organization and endothelial cell barrier function. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a selective inhibitor of Cdc42, another member of the Rho GTPase family. Inhibition of Cdc42 can lead to the compensatory activation of RhoJ, thus enhancing its role in cytoskeletal organization and cell movement. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $104.00 $364.00 | 7 | |
H-1152 is a more potent and selective inhibitor of ROCK than Y-27632. Inhibition of ROCK can shift the balance of Rho GTPase activity, potentially enhancing RhoJ activity to preserve cytoskeletal dynamics and cell motility. | ||||||
Thymosin β4 | 77591-33-4 | sc-396076 sc-396076A | 1 mg 100 mg | $134.00 $7140.00 | ||
Thymosin β4 is known to sequester G-actin monomers, thereby indirectly influencing actin polymerization. It can enhance RhoJ activity as part of its role in regulating the actin cytoskeleton and promoting cell migration. | ||||||