Date published: 2025-12-17

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Rho J Activators

Rho J Activators belong to a class of chemical compounds that play a pivotal role in cellular signaling pathways and are primarily known for their influence on the regulation of cell morphology and cytoskeletal dynamics. These activators are characterized by their ability to modulate the activity of Rho GTPases, a family of small G proteins that act as molecular switches, controlling various cellular processes such as cell migration, adhesion, and shape changes. Rho GTPases, including RhoA, RhoB, and RhoC, are key regulators of the actin cytoskeleton, and their activation is essential for various physiological processes.

Rho J Activators function by promoting the activation of Rho GTPases, leading to downstream signaling events that ultimately affect the organization of the actin cytoskeleton. This class of compounds can induce a shift in cellular morphology, often leading to the formation of stress fibers, which are bundles of actin filaments. These changes in cell shape and cytoskeletal rearrangements can have significant implications in various cellular processes, including cell motility, adhesion, and tissue development. Moreover, the modulation of Rho GTPase activity by Rho J Activators has been of interest in the fields of cell biology and research, as it provides a valuable tool for studying the underlying mechanisms of cell migration and cytoskeletal dynamics. Understanding these processes is crucial for unraveling fundamental cellular functions and their roles in health and disease.

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Items 11 to 12 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Jasplakinolide

102396-24-7sc-202191
sc-202191A
50 µg
100 µg
$180.00
$299.00
59
(1)

Jasplakinolide stabilizes actin filaments and can induce actin polymerization. This stabilization can lead to the activation of RhoJ as a response to changes in the actin cytoskeleton, influencing cell morphology and motility.

NSC 23766

733767-34-5sc-204823
sc-204823A
10 mg
50 mg
$148.00
$597.00
75
(4)

NSC23766 inhibits Rac1 by blocking its interaction with specific GEFs without affecting RhoJ. This selective Rac1 inhibition may enhance the activity of RhoJ indirectly by altering the balance of Rho GTPase signaling pathways in the cell.