Rho H Activators
Rho H Activators are a broad range of chemicals, primarily due to the complexity and interconnectivity of the Rho GTPase signaling network. Agents such as Phorbol 12-myristate 13-acetate (PMA) and EGF have wide-reaching effects on multiple cellular signaling pathways, but their potential to activate protein kinase C and EGFR respectively can indirectly steer Rho GTPase activities, inclusive of RhoH.
Furthermore, a significant subset of these molecules, such as Fasudil and H1152, target the Rho-associated protein kinase (ROCK). This kinase operates downstream of the Rho GTPases, including RhoH. By influencing ROCK, these chemicals invariably have a bearing on the upstream Rho GTPase functions. On the other end of the spectrum, compounds such as Latrunculin A and Jasplakinolide directly influence actin dynamics, a primary cellular process regulated by Rho GTPases. This offers another avenue through which RhoH's roles might be modulated.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Known to activate protein kinase C (PKC) which can indirectly regulate Rho GTPase activities, potentially influencing RhoH. | ||||||
Fasudil, Monohydrochloride Salt | 105628-07-7 | sc-203418 sc-203418A sc-203418B sc-203418C sc-203418D sc-203418E sc-203418F | 10 mg 50 mg 250 mg 1 g 2 g 5 g 10 g | $18.00 $33.00 $87.00 $168.00 $253.00 $496.00 $910.00 | 5 | |
A Rho kinase (ROCK) inhibitor; similar to Y-27632, by inhibiting ROCK, it can indirectly influence pathways associated with RhoH. | ||||||
Calpeptin | 117591-20-5 | sc-202516 sc-202516A | 10 mg 50 mg | $121.00 $456.00 | 28 | |
It's a calpain inhibitor. Calpain can regulate Rho GTPase signaling, and by inhibiting it, Calpeptin might indirectly modulate RhoH's associated pathways. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $104.00 $364.00 | 7 | |
Another inhibitor of ROCK. Its role in modulating the Rho-ROCK pathway can have implications for the processes in which RhoH is involved. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
This agent disrupts actin polymerization. Given the role of Rho GTPases in actin dynamics, it can indirectly influence the RhoH-involved processes. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Stabilizes actin filaments and affects Rho GTPase signaling. Its influence on actin dynamics can indirectly touch upon RhoH's role. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Inhibits myosin II, affecting actin-myosin interactions. Given Rho GTPases' role in actin dynamics, this can indirectly touch upon RhoH functions. | ||||||