RhebL1 Inhibitors
Common RhebL1 Inhibitors include, but are not limited to Wortmannin CAS 19545-26-7, LY 294002 CAS 154447-36-6, PD 98059 CAS 167869-21-8, U-0126 CAS 109511-58-2 and SP600125 CAS 129-56-6.
RhebL1, or Ras homolog enriched in brain like 1, is a member of the Ras superfamily of small GTPases, a group of proteins known for their pivotal roles in signal transduction and intracellular communication. Small GTPases, including RhebL1, function as molecular switches, cycling between active (GTP-bound) and inactive (GDP-bound) states. This switching mechanism is central to their ability to regulate a multitude of cellular processes, ensuring appropriate cellular responses to external or internal stimuli. The exact physiological role and pathways associated with RhebL1 are still under exploration, but its association with the Ras superfamily suggests its significance in cellular signaling and regulatory networks.
RhebL1 inhibitors are molecules designed to specifically target and inhibit the functional activity of RhebL1. The mode of action of these inhibitors can vary. Some might bind directly to the RhebL1 protein, preventing its activation or interaction with other proteins in its signaling pathway. Others might interfere with the process of switching between the GTP and GDP states, thereby hindering its ability to transmit signals. There are also inhibitors that could target proteins that interact with RhebL1, disrupting its normal function indirectly. With the growing interest in the Ras superfamily and its constituent proteins, RhebL1 inhibitors serve as valuable tools in research, aiding in the elucidation of RhebL1's role in cellular functions and its interactions with other cellular components.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent, covalent inhibitor of phosphoinositide 3-kinase (PI3K). By inhibiting PI3K, it can affect downstream effectors, including the Rheb family. The inhibition of PI3K can lead to reduced activation of AKT, which might indirectly increase the activity of the TSC complex, thereby inhibiting RhebL1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. Similar to wortmannin, LY294002's inhibition of PI3K can reduce AKT activation. This can lead to the TSC complex's increased activity, which in turn, may inhibit RhebL1 by promoting its GDP-bound (inactive) state. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a specific inhibitor of the mitogen-activated protein kinase (MAPK) pathway. While its primary target is not directly associated with RhebL1, inhibition of MAPK can have indirect effects on the mTOR pathway and potentially on RhebL1's activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective JNK inhibitor. The JNK pathway can interact with the mTOR pathway at various points, and its inhibition might indirectly influence RhebL1 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 inhibits p38 MAPK. The p38 MAPK pathway has been shown to interact with the mTOR pathway, suggesting potential indirect effects on RhebL1 when p38 MAPK is inhibited. | ||||||
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 | 612847-09-3 | sc-202048 sc-202048A | 1 mg 5 mg | $208.00 $270.00 | 29 | |
Akti-1/2 is an Akt inhibitor. Akt positively regulates mTORC1 by inhibiting the TSC1/2 complex. By inhibiting Akt, Akti-1/2 can potentially increase TSC activity, leading to the inhibition of RhebL1. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
PP242 is an mTOR inhibitor that directly inhibits both mTORC1 and mTORC2. While RhebL1 is an activator of mTORC1, inhibiting mTOR itself would lead to an overall down-regulation of the RhebL1/mTORC1 pathway. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
Torin1 is a potent inhibitor of both mTORC1 and mTORC2. Similar to PP242, even though RhebL1 can activate mTORC1, the direct inhibition of mTOR by Torin1 results in down-regulation of the RhebL1/mTORC1 pathway. | ||||||
KU 0063794 | 938440-64-3 | sc-361219 | 10 mg | $209.00 | ||
Ku-0063794 is a specific mTOR inhibitor affecting both mTORC1 and mTORC2. Its mechanism, similar to other mTOR inhibitors, would lead to an overall inhibitory effect on the RhebL1/mTORC1 signaling pathway. | ||||||