RecQL4 Activators

The chemical class termed RecQL4 Activators encompasses a diverse range of compounds that can influence the activity of RecQL4, a member of the RecQ helicase family integral to DNA repair and maintenance. These activators, while varied in their primary mechanisms of action, can modulate the function and dynamics of RecQL4 by targeting pathways or processes related to DNA repair and maintenance.

Among the notable members of this class are Cisplatin and Hydroxyurea. Cisplatin induces DNA damage, which can activate DNA repair pathways, thereby potentially influencing RecQL4 activity. Hydroxyurea, on the other hand, stalls DNA replication, potentially activating DNA repair mechanisms and influencing the dynamics and activity of RecQL4. Olaparib, an inhibitor of PARP, and ATR inhibitor (VE-821) and ATM inhibitor (KU-55933), both of which target kinases involved in the DNA damage response, can modulate DNA repair pathways, potentially affecting RecQL4 function. 5-Azacytidine, which induces DNA demethylation, and Camptothecin and Etoposide, both of which induce DNA damage, can activate DNA repair pathways, potentially influencing RecQL4. MMS (Methyl methanesulfonate) induces DNA alkylation damage, while Aphidicolin inhibits DNA polymerase, both potentially activating DNA repair mechanisms and influencing RecQL4. Nocodazole, which disrupts microtubules, and Bleomycin, another DNA damaging agent, can also activate DNA repair pathways, potentially influencing the activity and function of RecQL4.