RCC1 Activators
The class of RCC1 activators encompasses a diverse range of chemical compounds designed to modulate the activity of Regulator of Chromosome Condensation 1 (RCC1), a crucial regulator of mitotic events and nucleocytoplasmic transport. RCC1, responsible for generating Ran GTPase, plays a pivotal role in governing the dynamic organization of the mitotic spindle and nuclear transport processes. The activators selected for this class exert their effects through various mechanisms, directly or indirectly influencing RCC1 activity and impacting cellular processes related to cell cycle progression, nucleocytoplasmic transport, and mitotic events. GTPγS, a direct activator, mimics the active GTP-bound state of Ran, directly activating RCC1 and initiating the regulatory cascade that governs nucleocytoplasmic transport. Brefeldin A, an indirect activator, disrupts vesicular transport and the Golgi apparatus, leading to the activation of the DNA damage response (DDR) and indirectly activating RCC1, which is sensitive to DNA damage signals. Calmodulin Inhibitor W-7 indirectly activates RCC1 by inhibiting calmodulin and disrupting calcium-dependent signaling pathways, impacting the spatial regulation of Ran GTPase.
The class also includes indirect activators like 2-Methoxyestradiol, Sodium Orthovanadate, GDPβS, and Phorbol 12-myristate 13-acetate (PMA), which modulate RCC1 by affecting microtubule dynamics, tyrosine phosphorylation events, GDP-bound state of Ran, and protein kinase C (PKC)-mediated signaling, respectively. These compounds provide valuable tools for studying the regulatory mechanisms of RCC1 and its functional implications in diverse cellular processes. Furthermore, activators such as Nocodazole, Monastrol, Protein Kinase C Activator (PMA), and Epidermal Growth Factor (EGF) indirectly activate RCC1 by influencing GPCR-mediated signaling, microtubule dynamics, kinesin Eg5, PKC-mediated signaling, and EGFR-dependent signaling, respectively. Each of these activators offers a unique perspective on the complex interplay between RCC1 and the intricate regulatory networks that govern cell cycle progression, nucleocytoplasmic transport, and mitotic events.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A is a chemical activator that indirectly modulates RCC1. By inhibiting ADP-ribosylation factor (ARF), Brefeldin A disrupts vesicular transport and the Golgi apparatus, leading to the activation of the DNA damage response (DDR). | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
Calmodulin Inhibitor W-7 is a chemical activator that indirectly modulates RCC1. By inhibiting calmodulin, W-7 disrupts calcium-dependent signaling pathways, leading to alterations in the localization and activation of key regulatory proteins, including RCC1. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $71.00 $288.00 | 6 | |
2-Methoxyestradiol is a chemical activator that indirectly modulates RCC1. By targeting microtubules and disrupting their dynamics, 2-Methoxyestradiol triggers the spindle assembly checkpoint (SAC) and indirectly activates RCC1. The SAC activation prevents cell cycle progression, indirectly modulating RCC1, which relies on dynamic spindle microtubules for activation. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium Orthovanadate is a chemical activator that indirectly modulates RCC1. By inhibiting protein tyrosine phosphatases (PTPs), sodium orthovanadate enhances tyrosine phosphorylation events, leading to alterations in the localization and activation of key regulatory proteins, including RCC1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) is a chemical activator that indirectly modulates RCC1. By activating protein kinase C (PKC), PMA triggers downstream signaling events, leading to alterations in the localization and activation of key regulatory proteins, including RCC1. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a chemical activator that indirectly modulates RCC1. By disrupting microtubule dynamics, Nocodazole triggers the spindle assembly checkpoint (SAC) and indirectly activates RCC1. The SAC activation prevents cell cycle progression, indirectly modulating RCC1, which relies on dynamic spindle microtubules for activation. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a chemical activator that indirectly modulates RCC1. By inhibiting the kinesin Eg5, Monastrol disrupts mitotic spindle dynamics, leading to the activation of the spindle assembly checkpoint (SAC) and indirect activation of RCC1. The SAC activation prevents cell cycle progression, indirectly modulating RCC1, which relies on dynamic spindle microtubules for activation. | ||||||