RCC1 Inhibitors
The class of RCC1 inhibitors comprises a diverse array of chemical compounds designed to modulate the activity of Regulator of Chromosome Condensation 1 (RCC1), a pivotal regulator of mitotic events and nucleocytoplasmic transport. RCC1, responsible for the generation of Ran GTPase, plays a crucial role in governing the dynamic organization of the mitotic spindle and nuclear transport processes. The inhibitors selected for this class exert their effects through various mechanisms, indirectly influencing RCC1 activity and impacting cellular processes related to cell cycle progression, nucleocytoplasmic transport, and mitotic events. S-Trityl-L-Cysteine, one of the inhibitors, disrupts mitotic spindle dynamics by targeting Eg5, a kinesin motor protein, leading to the activation of the spindle assembly checkpoint (SAC) and inhibition of RCC1. Importazole interferes with nucleocytoplasmic transport by targeting importin-β, indirectly influencing RCC1 localization and Ran GTPase regulation. Leptomycin B, by inhibiting CRM1, stops the export of RCC1 from the nucleus, affecting its activation. These indirect modulation strategies highlight the intricate interplay between RCC1 and various cellular processes.
Several inhibitors, such as Aurora Kinase Inhibitor and BI 2536, target key regulators of mitotic progression, disrupting spindle dynamics and triggering the SAC, subsequently inhibiting RCC1. Thiazole Antibiotic induces cellular stress and activates p53, indirectly inhibiting RCC1 in response to stress signals. Gboxin targets mitochondrial complex I, leading to metabolic stress and AMPK activation, impacting RCC1 activity based on cellular energy status. The chemical class also includes inhibitors like Hesperadin and BI 6727, which target Aurora B kinase and Polo-like kinase 1 (PLK1), respectively, disrupting spindle dynamics and inhibiting RCC1 through the SAC. Cytarabine, a cytosine analog, induces DNA damage, activating the DNA damage response and indirectly inhibiting RCC1. KPT-330 disrupts nucleocytoplasmic transport by inhibiting XPO1, influencing RCC1 localization and Ran GTPase regulation. In summary, the RCC1 inhibitors form a diverse class of compounds employing various strategies to indirectly modulate RCC1 activity, offering valuable tools for unraveling the intricate regulatory networks governing cell cycle progression, nucleocytoplasmic transport, and mitotic events.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
S-Trityl-L-cysteine is a chemical inhibitor that indirectly modulates RCC1. By binding to and inhibiting Eg5, a kinesin motor protein, S-Trityl-L-cysteine disrupts mitotic spindle dynamics. This disruption triggers the spindle assembly checkpoint (SAC), preventing cell cycle progression and indirectly inhibiting RCC1, which relies on dynamic spindle microtubules for its activation. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
This Aurora kinase inhibitor is a chemical compound that indirectly modulates RCC1. By targeting Aurora kinases, which are crucial regulators of mitotic progression, this inhibitor disrupts spindle assembly and triggers the spindle assembly checkpoint (SAC). The SAC activation prevents cell cycle progression, indirectly inhibiting RCC1, which requires proper spindle dynamics for activation. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
BI 2536 is a chemical inhibitor that indirectly modulates RCC1. By targeting Polo-like kinase 1 (PLK1), a key regulator of mitotic progression, BI 2536 disrupts spindle dynamics and triggers the spindle assembly checkpoint (SAC). The SAC activation prevents cell cycle progression, indirectly inhibiting RCC1, which requires proper spindle dynamics for activation. | ||||||
Hesperadin | 422513-13-1 | sc-490384 | 10 mg | $304.00 | ||
Hesperadin is a chemical inhibitor that indirectly modulates RCC1. By targeting Aurora B kinase, a critical regulator of chromosome segregation, Hesperadin disrupts spindle dynamics and triggers the spindle assembly checkpoint (SAC). | ||||||
BI6727 | 755038-65-4 | sc-364432 sc-364432A sc-364432B sc-364432C sc-364432D | 5 mg 50 mg 100 mg 500 mg 1 g | $150.00 $1050.00 $1665.00 $3329.00 $4382.00 | 1 | |
BI 6727 is a chemical inhibitor that indirectly modulates RCC1. By targeting Polo-like kinase 1 (PLK1), a key regulator of mitotic progression, BI 6727 disrupts spindle dynamics and triggers the spindle assembly checkpoint (SAC). The SAC activation prevents cell cycle progression, indirectly inhibiting RCC1, which requires proper spindle dynamics for activation. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $150.00 $263.00 $518.00 $731.00 $1461.00 | 1 | |
1-β-D-Arabinofuranosylcytosine is a chemical inhibitor that indirectly modulates RCC1. As a cytosine analog, 1-β-D-Arabinofuranosylcytosine incorporates into DNA during replication, inducing DNA damage and activating the DNA damage response (DDR). The activation of DDR indirectly inhibits RCC1, which is sensitive to DNA damage signals. | ||||||
KPT 330 | 1393477-72-9 | sc-489062 | 5 mg | $173.00 | ||
KPT-330 is a chemical inhibitor that indirectly modulates RCC1. By inhibiting XPO1 (exportin-1), a nuclear export protein, KPT-330 disrupts nucleocytoplasmic transport, leading to alterations in the localization of key regulatory proteins, including RCC1. | ||||||