RBM20 Inhibitors
RBM20 Inhibitors are primarily tailored to intervene in the RNA splicing processes, given RBM20's pronounced role in alternative splicing of cardiac genes. Pladienolide B, E7107, and Meayamycin serve as representatives that target the SF3B1 subunit of the spliceosome. By inhibiting this key component of the splicing machinery, these chemicals can influence the alternative splicing processes that RBM20 oversees.
Isoginkgetin and HERBIMYCIN A, though structurally diverse, also focus on the inhibition of pre-mRNA splicing, drawing a route to impact RBM20's functionality indirectly. The mechanistic approach of Silvestrol, targeting the RNA helicase eIF4A, represents another avenue through which RBM20's splicing processes can be affected, albeit indirectly. Similarly, compounds such as TG003 act on regulators of splicing, namely CLK1 and CLK4, implying a to reduce RBM20's function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
A splicing inhibitor that targets the SF3B1 subunit of the spliceosome. It can affect alternative splicing processes. | ||||||
Isoginkgetin | 548-19-6 | sc-507430 | 5 mg | $225.00 | ||
A biflavonoid compound that can inhibit pre-mRNA splicing, thus indirectly affecting RBM20's role. | ||||||
Spliceostatin A | 391611-36-2 | sc-507481 | 1 mg | $1800.00 | ||
Binds to SF3B complex and inhibits splicing. By affecting the splicing machinery, it can influence RBM20's function. | ||||||
Chlorhexidine | 55-56-1 | sc-252568 | 5 g | $103.00 | 3 | |
A disinfectant with broad applications; it can affect RNA splicing, potentially influencing RBM20's splicing roles. | ||||||
Herbimycin A | 70563-58-5 | sc-3516 sc-3516A | 100 µg 1 mg | $277.00 $1532.00 | 13 | |
Known to affect splicing, it can thus indirectly impact the alternative splicing processes overseen by RBM20. | ||||||
Silvestrol | 697235-38-4 | sc-507504 | 1 mg | $920.00 | ||
Affects RNA helicase eIF4A and can indirectly influence splicing mechanisms and RBM20. | ||||||