RBM20 Activators
RBM20 Activators includes compounds that can indirectly influence the activity of RNA Binding Motif Protein 20 (RBM20), a protein primarily involved in the regulation of alternative splicing, especially in genes related to cardiac function. Direct chemical activators of RBM20 are not well established, but various compounds that affect spliceosome function, RNA processing, and cardiac gene expression can activate RBM20 activity.
Compounds such as Pladienolide B and its derivative E7107 target the spliceosome, the complex responsible for RNA splicing. By affecting the spliceosome, these compounds can indirectly influence the function of splicing factors like RBM20. Similarly, Spliceostatin A, another spliceosome modulator, has effects on splicing processes involving RBM20.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $143.00 $694.00 | ||
Cardiac glycosides impact cardiac gene expression, potentially indirectly affecting RBM20-related pathways. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
HSP90 inhibitors can affect protein folding and stability, potentially influencing RBM20 function. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $31.00 $41.00 $56.00 $163.00 $337.00 $592.00 | 2 | |
Betaine is involved in methylation processes and could influence RNA processing and RBM20 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitors affect various cellular processes, including protein synthesis, potentially impacting RBM20 activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
HDAC inhibitors can alter gene expression, possibly influencing RBM20 function. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Inhibitors of RNA Polymerase II can affect pre-mRNA synthesis, potentially impacting RBM20 activity. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Kinase inhibitors can affect signaling pathways, potentially impacting RBM20 and related splicing. | ||||||