RASAL3 Activators
RASAL3 activators belong to a distinctive chemical class designed to modulate the activity of the RASAL3 gene, a critical component within the broader RAS signaling pathway. The RAS pathway plays a pivotal role in cellular processes such as proliferation, differentiation, and survival. RASAL3, specifically, is a RAS GTPase-activating protein (GAP), functioning as a negative regulator by promoting the hydrolysis of GTP to GDP, thereby inactivating RAS. The class of compounds known as RASAL3 activators seeks to enhance the activity of RASAL3, consequently fine-tuning the intricate balance of RAS signaling.
Structurally, RASAL3 activators are characterized by their specific interaction with the RASAL3 protein, eliciting a conformational change that augments its catalytic efficiency. These compounds act as molecular switches, promoting the intrinsic GTPase activity of RASAL3 and facilitating the termination of downstream signaling events initiated by RAS. The design and development of RASAL3 activators involve a comprehensive understanding of the molecular mechanisms governing RAS signaling, ensuring a precise and targeted modulation of cellular responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tipifarnib | 192185-72-1 | sc-364637 | 10 mg | $720.00 | ||
Acts as a Farnesyltransferase Inhibitor (FTI), impacting the farnesylation process involved in RAS protein activation, including RASAL3. | ||||||
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $114.00 $166.00 $947.00 | 19 | |
Functions as a MEK Inhibitor, affecting the MAPK pathway and potentially influencing RASAL3 activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates Protein Kinase C (PKC), a pathway that may indirectly impact RASAL3 activation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Inhibits PI3K, a pathway connected to RAS signaling, which could indirectly modulate RASAL3 activation. | ||||||
Farnesyl thiosalicylic acid | 162520-00-5 | sc-205322 sc-205322A | 1 mg 5 mg | $61.00 $82.00 | 15 | |
Functions as an H-Ras Inhibitor, directly impacting the Ras protein family, including RASAL3. | ||||||
Erlotinib, Free Base | 183321-74-6 | sc-396113 sc-396113A sc-396113B sc-396113C sc-396113D | 500 mg 1 g 5 g 10 g 100 g | $87.00 $135.00 $293.00 $505.00 $3827.00 | 42 | |
Inhibits EGFR, a receptor linked to RAS signaling, potentially influencing RASAL3 activation. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
Modulates Notch signaling, which may indirectly influence RASAL3 activation. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
Modulates the Wnt signaling pathway, potentially impacting RASAL3 activation indirectly. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Acts as a cAMP modulator, influencing a pathway that may have connections to RASAL3 activation. | ||||||