Ras Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $219.00 $634.00 | 5 | |
Manumycin A is a unique compound that acts as a potent inhibitor of Ras proteins, disrupting their signaling pathways. It interacts with the Ras GTPase through specific binding sites, leading to altered conformational states that hinder GTP binding. This interaction affects downstream signaling cascades, influencing cellular proliferation and differentiation. Additionally, its structural features allow for selective targeting of Ras isoforms, enhancing its specificity in modulating cellular functions. | ||||||
L-744,832 Dihydrochloride | 1177806-11-9 | sc-221800 sc-221800A | 5 mg 25 mg | $561.00 $1832.00 | 2 | |
L-744,832 Dihydrochloride is a selective inhibitor of Ras proteins, characterized by its ability to disrupt the nucleotide exchange process. It binds to the Ras protein with high affinity, stabilizing an inactive conformation that prevents GTP from associating. This inhibition alters the kinetics of downstream signaling pathways, effectively modulating cellular responses. Its unique structural attributes facilitate targeted interactions, providing insights into Ras-mediated regulatory mechanisms. | ||||||
Farnesyl thiosalicylic acid | 162520-00-5 | sc-205322 sc-205322A | 1 mg 5 mg | $61.00 $82.00 | 15 | |
Farnesyl thiosalicylic acid acts as a potent modulator of Ras signaling by interfering with post-translational modifications essential for Ras membrane localization. Its unique thiosalicylic acid moiety enhances binding to the farnesylation site, promoting conformational changes that hinder Ras activation. This compound exhibits distinct reaction kinetics, influencing the dynamics of protein-protein interactions and downstream signaling cascades, thereby providing a nuanced approach to studying Ras-related pathways. | ||||||
FTI-276 trifluoroacetate salt | 1217471-51-6 | sc-215057 sc-215057A | 1 mg 5 mg | $148.00 $518.00 | ||
FTI-276 trifluoroacetate salt functions as a selective inhibitor of Ras by disrupting its farnesylation process, crucial for membrane anchoring. The trifluoroacetate group enhances solubility and stability, facilitating its interaction with the farnesyltransferase enzyme. This compound exhibits unique binding kinetics, altering the conformational landscape of Ras, which impacts its downstream signaling pathways. Its distinct molecular interactions provide insights into the regulatory mechanisms of Ras activity. | ||||||
Ras/Rac Transformation Blocker, SCH 51344 | 171927-40-5 | sc-204231 | 10 mg | $146.00 | 4 | |
SCH 51344 acts as a potent Ras/Rac transformation blocker by interfering with the post-translational modifications essential for Ras activation. Its unique structure allows it to selectively bind to the Ras protein, stabilizing an inactive conformation and preventing downstream signaling. The compound's specific interactions with key residues alter the dynamics of Ras, providing a deeper understanding of its regulatory mechanisms and the intricate pathways involved in cellular signaling. | ||||||