FTI-276 trifluoroacetate salt (CAS 1217471-51-6)

FTI-276 trifluoroacetate salt is a potent and selective inhibitor of farnesyltransferase (FTase), an enzyme responsible for the post-translational modification of proteins through farnesylation. This biochemical process is critical for the proper functioning of various proteins, including the oncogenic protein Ras, which plays a key role in signal transduction pathways that control cell growth and differentiation. By inhibiting FTase, FTI-276 trifluoroacetate salt disrupts the proper localization and function of these proteins within the cell, thereby affecting cellular signaling mechanisms. This compound has become useful in research focused on understanding the mechanisms of cell proliferation, signal transduction pathways, and the role of protein prenylation in disease pathogenesis. Its ability to selectively target FTase without affecting geranylgeranyltransferase, another enzyme involved in protein prenylation, makes FTI-276 trifluoroacetate salt particularly useful for dissecting the specific contributions of farnesylated proteins in cellular processes.