Molecular structure of L-744,832 Dihydrochloride, CAS Number: 1177806-11-9
L-744,832 Dihydrochloride (CAS 1177806-11-9)
See product citations (2)
Alternate Names:
L-744,832 Dihydrochloride is known as an FTase inhibitor.
Application:
L-744,832 Dihydrochloride is a Ras farnesyltransferase inhibitor that arrests cells at G1
CAS Number:
1177806-11-9
Purity:
≥98%
Molecular Weight:
632.70
Molecular Formula:
C26H45N3O6S2•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-744,832 Dihydrochloride is a Ras farnesyltransferase inhibitor. L-744,832 Dihydrochloride induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis1. L-744,832 Dihydrochloride can also induce p21 expression and arrests cells at G12. It has been observed that L-744,832 Dihydrochloride causes enhanced mitotic sensitivity to taxol3. This is a powerful and selective peptidomimetic farnesyltransferase (FTase) inhibitor, which contains thiol and can penetrate cells effectively. It possesses remarkable anti-tumor properties.
L-744,832 Dihydrochloride (CAS 1177806-11-9) References
- In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells. | Mahgoub, N., et al. 1999. Blood. 94: 2469-76. PMID: 10498620
- A peptidomimetic inhibitor of ras functionality markedly suppresses growth of human prostate tumor xenografts in mice. Prospects for long-term clinical utility. | Sirotnak, FM., et al. 2000. Cancer Chemother Pharmacol. 46: 79-83. PMID: 10912583
- K-Ras-independent effects of the farnesyl transferase inhibitor L-744,832 on cyclin B1/Cdc2 kinase activity, G2/M cell cycle progression and apoptosis in human pancreatic ductal adenocarcinoma cells. | Song, SY., et al. 2000. Neoplasia. 2: 261-72. PMID: 10935512
- Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2. | Alcock, RA., et al. 2002. Oncogene. 21: 7883-90. PMID: 12420225
- Potentiated antitumor effects of a combination therapy with a farnesyltransferase inhibitor L-744,832 and butyrate in vitro. | Kopec, M., et al. 2004. Oncol Rep. 11: 1127-31. PMID: 15069557
- Effect of the farnesyl transferase inhibitor L-744,832 on the colon cancer cell line DLD-1 and its combined use with radiation and 5-FU. | Kavgaci, H., et al. 2005. Chemotherapy. 51: 319-23. PMID: 16224182
- A combined treatment of HeLa cells with the farnesyl protein transferase inhibitor L-744,832 and cisplatin significantly increases the therapeutic effect as compared to cisplatin monotherapy. | Wesierska-Gadek, J., et al. 2008. J Cell Biochem. 104: 189-201. PMID: 18022825
- Farnesyl transferase inhibitors induce extended remissions in transgenic mice with mature B cell lymphomas. | Field, KA., et al. 2008. Mol Cancer. 7: 39. PMID: 18489761
- Delayed rejection of MHC class II-disparate skin allografts in mice treated with farnesyltransferase inhibitors. | Gaylo, AE., et al. 2009. Transpl Immunol. 20: 163-70. PMID: 18930822
- Propiconazole-enhanced hepatic cell proliferation is associated with dysregulation of the cholesterol biosynthesis pathway leading to activation of Erk1/2 through Ras farnesylation. | Murphy, LA., et al. 2012. Toxicol Appl Pharmacol. 260: 146-54. PMID: 22361350
- Prenyltransferases regulate CD20 protein levels and influence anti-CD20 monoclonal antibody-mediated activation of complement-dependent cytotoxicity. | Winiarska, M., et al. 2012. J Biol Chem. 287: 31983-93. PMID: 22843692
- Heteronemin, a marine natural product, sensitizes acute myeloid leukemia cells towards cytarabine chemotherapy by regulating farnesylation of Ras. | Saikia, M., et al. 2018. Oncotarget. 9: 18115-18127. PMID: 29719594
- Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. | Kohl, NE., et al. 1995. Nat Med. 1: 792-7. PMID: 7585182
- A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. | Barrington, RE., et al. 1998. Mol Cell Biol. 18: 85-92. PMID: 9418856
- Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice. | Mangues, R., et al. 1998. Cancer Res. 58: 1253-9. PMID: 9515813
Inhibitor of:
Farnesyl Transferase, GGPS1 (geranylgeranyl diphosphate synthase 1), and Ras.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-744,832 Dihydrochloride, 5 mg | sc-221800 | 5 mg | $561.00 | |||
L-744,832 Dihydrochloride, 25 mg | sc-221800A | 25 mg | $1832.00 |