Rap 2A Inhibitors
Rap 2A inhibitors belong to a distinctive chemical class that specifically targets the Ras-related protein 2A (Rap 2A). Rap 2A is a member of the Ras superfamily of small GTPases, crucial regulators of cellular processes such as signal transduction, cell proliferation, and cytoskeletal dynamics. These inhibitors are designed to modulate the activity of Rap 2A, thereby influencing downstream cellular pathways associated with this GTPase.
The chemical structures of Rap 2A inhibitors are characterized by specific motifs and functional groups that interact with key binding sites on Rap 2A, disrupting its normal GTPase activity. By selectively inhibiting Rap 2A, these compounds exert a regulatory influence on cellular events mediated by ths GTPase. The development of Rap 2A inhibitors involves a meticulous understanding of the structural and biochemical aspects of Rap 2A, guiding the rational design of molecules with high specificity and affinity for their target. Researchers explore various synthetic strategies to optimize the pharmacokinetic and pharmacodynamic properties of these inhibitors, aiming to enhance their effectiveness in cellular models.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor, which may affect downstream Rap2A signaling by altering kinase activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibits MEK, which is upstream of ERK signaling, potentially affecting Rap2A-related pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, which could influence Rap2A signaling by impacting mTORC1 and mTORC2 complexes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor, which may disrupt Rap2A downstream signaling. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Inhibits ROCK kinase, potentially affecting actin cytoskeleton dynamics and Rap2A-related processes. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
Inhibits c-Raf kinase, which could alter Rap2A activation state and its signaling pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, which may affect Rap2A signaling indirectly by modulating JNK activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
P38 MAP kinase inhibitor, which could influence Rap2A-related cellular responses. | ||||||
ZM 336372 | 208260-29-1 | sc-202857 | 1 mg | $46.00 | 2 | |
A c-Raf inhibitor that might have an effect on Rap2A-mediated signaling pathways. | ||||||
SL-327 | 305350-87-2 | sc-200685 sc-200685A | 1 mg 10 mg | $107.00 $332.00 | 7 | |
Inhibits MEK and could have an impact on ERK signaling, which is relevant to Rap2A activity. | ||||||