Ral A Activators
The chemical class of Ral A Activators encompasses a variety of compounds that influence Ral A activity through different mechanisms and pathways. These compounds are not direct activators of Ral A but interact with cellular processes and signaling pathways that lead to its activation. GTP is fundamental for the activation of Ral A, as it facilitates the transition of Ral A from an inactive to an active state. Growth factors like EGF and insulin activate Ral A through their respective receptor-mediated signaling pathways. Farnesyl pyrophosphate and geranylgeranyl pyrophosphate are crucial for the post-translational modification of Ral A, enabling its proper localization and function.
Compounds like H-Ras and PMA activate Ral A through different signaling cascades, involving protein kinases and GTPase family members. Calmodulin, through its interaction with various cellular enzymes, influences the pathways leading to Ral A activation. Similarly, TGF-beta modulates Ral A activity as part of its role in cell regulation. PIK-75 and LY294002, both PI3K inhibitors, demonstrate how the inhibition of one pathway can influence another, in this case, the PI3K/Akt pathway's role in Ral A activity. NF449, a Gsα subunit inhibitor, also demonstrates the interconnected nature of cellular signaling pathways and their influence on Ral A activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanosine-5′-Triphosphate, Disodium salt | 86-01-1 | sc-507564 | 1 g | $700.00 | ||
As a guanosine triphosphate, GTP is essential for Ral A activation as it facilitates the transition from an inactive GDP-bound state to an active GTP-bound state. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin can stimulate Ral A activation as part of its role in regulating metabolic processes, likely through PI3K-Akt signaling. | ||||||
Farnesyl pyrophosphate ammonium salt | 13058-04-3 | sc-200847 sc-200847A | 1 mg 5 mg | $469.00 $1938.00 | ||
As a precursor in the biosynthesis of cholesterol and other isoprenoids, farnesyl pyrophosphate is involved in the post-translational modification of Ral A, which is critical for its activation. | ||||||
Geranylgeranylpyrophosphate triammonium salt | 6699-20-3 | sc-200849 | 200 µg | $120.00 | ||
Similar to farnesyl pyrophosphate, this compound is involved in post-translational modification of Ral A, essential for its proper localization and function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which has been shown to lead to the activation of Ral A. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $232.00 | ||
Calmodulin, by interacting with various kinases and phosphatases, can influence the signaling pathways leading to Ral A activation. | ||||||
PIK-75, hydrochloride | 372196-77-5 | sc-296089 sc-296089A | 1 mg 5 mg | $28.00 $122.00 | ||
As a PI3K inhibitor, PIK-75 can modulate Ral A activity through the PI3K/Akt signaling pathway. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $199.00 $460.00 $1479.00 | 1 | |
As a potent Gsα subunit inhibitor, NF449 can indirectly influence Ral A activity through G protein-coupled receptor signaling pathways. | ||||||