Calmodulin (human), (recombinant) (CAS 73298-54-1)

Calmodulin (human), (recombinant) is a synthetic form of the human calmodulin protein produced through recombinant DNA technology. Calmodulin is a calcium-binding protein that plays a role in regulating various cellular processes by interacting with and activating specific target proteins. Calmodulin (human), (recombinant) is widely used in scientific research and experimental applications. Its ability to bind calcium ions and activate specific target proteins makes it useful for studying calcium signaling pathways and the functional consequences of calmodulin-mediated protein activation. It functions as a versatile activator for various proteins involved in calcium signaling. It binds to calcium ions and undergoes a conformational change, enabling it to interact with specific target proteins. Some of the key targets activated by calmodulin include Nitric Oxide Synthase (NOS), Phosphodiesterase, and Calmodulin-dependent Protein Kinase (CaMK). Calmodulin activates NOS, an enzyme responsible for the production of nitric oxide (NO), a signaling molecule involved in various physiological processes, including vasodilation, neurotransmission, and immune response. Calmodulin can also activate certain isoforms of PDE, enzymes that regulate cyclic nucleotide signaling pathways. Activation of PDE by calmodulin leads to the breakdown of cyclic nucleotides such as cAMP or cGMP, modulating intracellular signaling cascades. Calmodulin also serves as an essential activator for several isoforms of CaMK, a group of protein kinases involved in various cellular processes, including neuronal signaling, learning, and memory. Upon binding calcium-activated calmodulin, CaMK becomes phosphorylated and initiates downstream signaling events.