Farnesyl pyrophosphate ammonium salt, in ethanol CAS: 13058-04-3
MF: C15H25O7P2•3NH4
MW: 433.42
An isoprenoid farnesyl donor.

Farnesyl pyrophosphate ammonium salt, in ethanol (CAS 13058-04-3)

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Synonym: FPP.3NH4
Application An isoprenoid farnesyl donor
CAS 등록번호: 13058-04-3
순도: ≥98%
분자량: 433.42
분자식: C15H25O7P23NH4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Farnesyl pyrophosphate ammonium salt, in ethanol, is an isoprenoid farnesyl-donor which is utilized by farnesyltransferase. It is also used for prenylation of several low molecular mass G proteins, including Ras. FPP has been shown to negate the inhibitory effects of cell growth for cells grown in high glucose conditions as well as to reverse the growth inhibitory effects of statins on variant human embryonic stem cells and cancer cells. FPP has also been detected in Alzheimer′s patients brains in elevated levels. Farnesyl pyrophosphate ammonium salt is an inhibitor of P2Y12. Concentration: 2 mg/mL in 0.25M ammonium bicarbonate containing 70% ethanol.


References

1. Pompliano, D.L., et al. 1992. Biochemistry. 31: 3800-3807. PMID: 1567835
2. Reiss, Y., et al. 1992. J. Biol. Chem. 267: 6403-6408. PMID: 1556143
3. Gauthaman, K., et al. 2009. Br. J. Pharmacol. 157: 962-973. PMID: 19438511
4. Ye, Y., et al. 2009. FEBS Lett. 583: 2997-3003. PMID: 19716825
5. Mather, A., et al. 2009. Int. J. Biochem. Cell Biol. 41: 561-569. PMID: 18692592
6. Hooff, G.P., et al. 2010. Biochim Biophys Acta.180: 896-905. PMID: 20382260

사용법 :
Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Formulation :
0.25M ammonium bicarbonate containing 70% ethanol
Physical State :
Liquid
용해도 :
Soluble in water.
저장 :
Store at -20° C
비등점 :
78° C
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
1
PubChem CID :
71299715
MDL Number :
MFCD00189688
SMILES :
CC(=CCC/C(=C/CC/C(=C/COP(=O)(O)OP(=O)(O)O)/C)/C)C.N.N.N

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