Date published: 2026-5-30

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RAI15 Inhibitors

RAI15 inhibitors are a class of chemical compounds designed to target and inhibit the function of RAI15 (Retinoic Acid-Induced 15), a protein involved in cellular processes such as gene regulation, development, and differentiation. RAI15 is associated with the retinoic acid signaling pathway, which is activated by retinoic acid, a derivative of vitamin A that plays a critical role in controlling gene expression. Proteins like RAI15 function as downstream effectors of retinoic acid signaling, modulating specific transcriptional programs that influence cellular behavior. RAI15 is believed to regulate gene expression by interacting with other transcriptional regulators or directly binding to DNA to modulate the activity of retinoic acid-responsive genes. Inhibitors of RAI15 work by blocking its ability to engage with target DNA sequences or by interfering with its interactions with other regulatory proteins, thus preventing it from exerting its influence on gene transcription.

Inhibiting RAI15 disrupts its role in regulating gene expression, leading to alterations in cellular differentiation, growth, and other processes governed by retinoic acid signaling. By preventing RAI15 from functioning correctly, these inhibitors can impact the transcription of key genes involved in development and cellular homeostasis. Researchers use RAI15 inhibitors to investigate the specific functions of this protein in retinoic acid-mediated pathways and to understand how it contributes to broader regulatory networks within cells. These inhibitors are valuable tools for studying how RAI15 influences the transcriptional landscape in response to environmental or developmental cues. Additionally, RAI15 inhibitors provide insights into the larger context of retinoic acid signaling, helping researchers explore how this pathway coordinates complex cellular processes. Through the study of RAI15 inhibitors, scientists gain a deeper understanding of the molecular mechanisms that regulate gene expression in response to retinoic acid and the role of proteins like RAI15 in fine-tuning cellular responses.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Histone Lysine Methyltransferase Inhibitor Inhibitor

935693-62-2 (free base)sc-202651
5 mg
$151.00
4
(1)

A diazepin-quinazolin-amine derivative known to inhibit G9a and GLP histone lysine methyltransferases, which may affect SMYD5 activity by altering the overall histone methylation landscape.

Chaetocin

28097-03-2sc-200893
200 µg
$126.00
5
(1)

A thiodioxopiperazine that is a known inhibitor of SUV39H1, a histone methyltransferase. By inhibiting related enzymes, it could influence the methylation status of substrates that SMYD5 might act upon.

UNC0638

1255580-76-7sc-397012
10 mg
$315.00
(0)

An inhibitor of G9a and GLP that could indirectly affect SMYD5 function by changing the histone methylation pattern and potentially altering SMYD5's enzymatic activity on shared substrates.

MS-275

209783-80-2sc-279455
sc-279455A
sc-279455B
1 mg
5 mg
25 mg
$24.00
$90.00
$212.00
24
(2)

A benzamide histone deacetylase inhibitor that, while not directly affecting methylation, could alter chromatin structure in a way that indirectly impacts SMYD5’s ability to access or methylate histones.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

A flavonoid that has been shown to inhibit a range of kinases and could interfere with signaling pathways that modulate the activity or expression of SMYD5.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

A morpholine derivative that inhibits PI3K, which may indirectly influence SMYD5 activity through alterations in cell signaling pathways.

Disulfiram

97-77-8sc-205654
sc-205654A
50 g
100 g
$53.00
$89.00
7
(1)

An inhibitor of acetaldehyde dehydrogenase, but it has also been shown to chelate copper, potentially disrupting the function of copper-dependent enzymes, which may include histone modifying enzymes like SMYD5.

Mocetinostat

726169-73-9sc-364539
sc-364539B
sc-364539A
5 mg
10 mg
50 mg
$214.00
$247.00
$1463.00
2
(1)

A benzamide histone deacetylase inhibitor that could alter the chromatin state, thus potentially affecting SMYD5's ability to methylate its histone targets.

Anacardic Acid

16611-84-0sc-202463
sc-202463A
5 mg
25 mg
$102.00
$204.00
13
(1)

A natural compound found in cashew nut shell liquid, known to inhibit histone acetyltransferases, potentially altering the transcriptional environment in which SMYD5 operates.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$60.00
$265.00
$1000.00
163
(3)

A peptide aldehyde that inhibits proteasomes, potentially affecting protein turnover and indirectly influencing the cellular context in which SMYD5 functions.