Rab 23 Inhibitors
Rab 23 inhibitors are a class of chemical compounds that specifically target the Rab 23 protein, a member of the Rab family of small GTPases. Rab proteins are key regulators of intracellular membrane trafficking, including vesicle formation, movement, and fusion. Rab 23, in particular, is involved in controlling the trafficking of vesicles within the endocytic and exocytic pathways, as well as regulating key signaling pathways such as the Hedgehog signaling pathway. Rab 23 cycles between an active GTP-bound state and an inactive GDP-bound state, and its activity is crucial for maintaining the proper flow of cellular materials and signals. Inhibitors of Rab 23 disrupt this cycle, leading to alterations in vesicular transport and potentially affecting downstream signaling events related to its role in cellular communication and organization.
By inhibiting Rab 23, researchers can gain deeper insights into its specific functions in regulating membrane trafficking and cellular organization. Rab 23 inhibitors allow for the investigation of how disruptions in vesicular transport can impact processes like signal transduction, cellular polarity, and the maintenance of cellular compartments. The ability to selectively block Rab 23 activity is a valuable tool for studying how the precise control of intracellular transport contributes to overall cellular function, as well as how misregulation of these processes might affect cellular dynamics. These inhibitors also aid in exploring the broader regulatory mechanisms that govern the Rab GTPase family and their interactions with other proteins involved in vesicle trafficking. Overall, Rab 23 inhibitors are an important resource for elucidating the intricacies of membrane transport and its role in maintaining cellular homeostasis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a potent inhibitor of ROCK (Rho-associated protein kinase), which is involved in actin cytoskeleton organization. By inhibiting ROCK, Y-27632 may indirectly affect Rab23 function due to the interconnectedness of cytoskeletal dynamics and vesicular trafficking. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $148.00 $597.00 | 75 | |
NSC 23766 is a Rac1 inhibitor. Since Rac1 is a part of the Rho family of GTPases and plays a crucial role in actin organization, its inhibition can potentially influence Rab23-mediated processes, particularly in vesicle movement and cytoskeletal organization. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
ML141 is a potent, selective inhibitor of Cdc42, another member of the Rho family of GTPases. Cdc42 influences actin polymerization and cellular morphology, which are processes potentially linked to Rab23's function in vesicle trafficking. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $273.00 | 6 | |
SecinH3 selectively inhibits cytohesins, which are guanine nucleotide exchange factors (GEFs) for several small GTPases. By inhibiting these GEFs, SecinH3 might indirectly affect Rab23 function in vesicular trafficking and cellular signaling. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A is a fungal metabolite that inhibits ADP-ribosylation factor (Arf) GTPases. As Arf GTPases are involved in vesicle formation, their inhibition by Brefeldin A may indirectly disrupt Rab23-related trafficking pathways. | ||||||
PKF118-310 | 84-82-2 | sc-364590 sc-364590A | 5 mg 25 mg | $176.00 $638.00 | ||
PKF118-310 (Toxoflavin) is a small molecule that inhibits PAK1, a kinase involved in actin filament dynamics and cellular motility. As Rab23 is part of the cellular machinery that interfaces with the actin cytoskeleton, toxoflavin might indirectly affect its function. | ||||||
IPA 3 | 42521-82-4 | sc-204016 sc-204016A | 5 mg 50 mg | $92.00 $449.00 | 6 | |
IPA-3 is a selective inhibitor of PAK1. By targeting PAK1, IPA-3 can potentially influence processes related to Rab23, as PAK1 is involved in actin dynamics and membrane trafficking. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $315.00 $1020.00 | 5 | |
CK-666 is an Arp2/3 complex inhibitor. The Arp2/3 complex plays a crucial role in the formation of branched actin networks, which are critical for vesicular trafficking, potentially affecting Rab23's role in this process. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is a formin inhibitor. Formins are involved in the polymerization of unbranched actin filaments. Since Rab23 is associated with vesicle movement along actin filaments, SMIFH2 may indirectly impact its function. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore is a non-competitive inhibitor of dynamin, a GTPase important for vesicle scission. Since Rab23 is involved in vesicle trafficking, inhibition of dynamin by Dynasore could indirectly influence Rab23-mediated processes. | ||||||