Molecular structure of NSC 23766, CAS Number: 733767-34-5
NSC 23766 (CAS 733767-34-5)
See product citations (75)
Alternate Names:
NSC 23766 is also known as Rac1 Inhibitor.
Application:
NSC 23766 is a potent Rac1 inhibitor and specific inhibitor of the binding and activation of Rac GTPase.
CAS Number:
733767-34-5
Purity:
≥95%
Molecular Weight:
530.96
Molecular Formula:
C24H35N7•3HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
NSC 23766 is a specific inhibitor of the binding and activation of RAC GTPase. In vitro studies have shown that NSC 23766 inhibits Rac 1 binding and activation via Rac-specific GEF Trio or Tiam 1 without altering RhoA or Cdc42 binding or activation. Membrane type 1-matrix metalloproteinases (MT-1MMP) expression in CB CD34+ cells has been reported to decrease in the presence of NSC 23766. Silveta compressa investigations indicate that NSC 23766 depolarizes endomembrane cycling, altered polar adhesive secretion, and tip growth. NSC 23766 is also known as Rac1 Inhibitor, NSC23766, Nsc-23766, 6-N-[2-[5-(diethylamino)pentan-2-ylamino]-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine trihydrochloride, and N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride.
NSC 23766 (CAS 733767-34-5) References
- Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. | Gao, Y., et al. 2004. Proc Natl Acad Sci U S A. 101: 7618-23. PMID: 15128949
- The Rac1 inhibitor, NSC23766, depolarizes adhesive secretion, endomembrane cycling, and tip growth in the fucoid alga, Silvetia compressa. | Hable, WE., et al. 2008. Planta. 227: 991-1000. PMID: 18183417
- Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin-induced barrier breakdown. | Baumer, Y., et al. 2009. J Cell Physiol. 220: 716-26. PMID: 19472214
- Fanca-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766. | Milsom, MD., et al. 2009. Haematologica. 94: 1011-5. PMID: 19491337
- ERK activation of p21 activated kinase-1 (Pak1) is critical for medulloblastoma cell migration. | Yuan, L., et al. 2010. Clin Exp Metastasis. 27: 481-91. PMID: 20526801
- Hyaluronic acid and thrombin upregulate MT1-MMP through PI3K and Rac-1 signaling and prime the homing-related responses of cord blood hematopoietic stem/progenitor cells. | Shirvaikar, N., et al. 2011. Stem Cells Dev. 20: 19-30. PMID: 20629539
- Role of Rac1 GTPase in NADPH oxidase activation and cognitive impairment following cerebral ischemia in the rat. | Raz, L., et al. 2010. PLoS One. 5: e12606. PMID: 20830300
- NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors. | Levay, M., et al. 2013. J Pharmacol Exp Ther. 347: 69-79. PMID: 23887096
- The Rac1 inhibitor NSC23766 exerts anti-influenza virus properties by affecting the viral polymerase complex activity. | Dierkes, R., et al. 2014. PLoS One. 9: e88520. PMID: 24523909
- Delayed treatment with NSC23766 in streptozotocin-induced diabetic rats ameliorates post-ischemic neuronal apoptosis through suppression of mitochondrial p53 translocation. | Liao, J., et al. 2014. Neuropharmacology. 85: 508-16. PMID: 24953831
- Programmed Application of Transforming Growth Factor β3 and Rac1 Inhibitor NSC23766 Committed Hyaline Cartilage Differentiation of Adipose-Derived Stem Cells for Osteochondral Defect Repair. | Zhu, S., et al. 2014. Stem Cells Transl Med. 3: 1242-51. PMID: 25154784
- The Rac1 inhibitor NSC23766 suppresses CREB signaling by targeting NMDA receptor function. | Hou, H., et al. 2014. J Neurosci. 34: 14006-12. PMID: 25319697
- The Role of Rac1 on Carbachol-induced Contractile Activity in Detrusor Smooth Muscle from Streptozotocin-induced Diabetic Rats. | Evcim, AS., et al. 2015. Basic Clin Pharmacol Toxicol. 116: 476-84. PMID: 25382267
- MicroRNA-199a-5p Regulates the Proliferation of Pulmonary Microvascular Endothelial Cells in Hepatopulmonary Syndrome. | Zeng, J., et al. 2015. Cell Physiol Biochem. 37: 1289-300. PMID: 26430741
- Effects of spermine on the proliferation and migration of porcine intestinal epithelial cells. | Xu, X., et al. 2021. Anim Biotechnol. 1-8. PMID: 34369303
Inhibitor of:
2410002O22Rik, 4930504O13Rik, 4931406P16Rik, A730069N07Rik, ABR, ACBD3, Adducin β, AGP-3, ANKMY2, ARA160, ArgBP2, ARHGAP10, ARHGAP23, ARHGAP4, ARHGEF15, ARHGEF3, ARHGEF37, ARHGEF38, ARHGEF39, ARHGEF5_Arhgef5, ARHGEF5L, ARHGEF9, ARL14EPL, ARL4D, ARL5A, ARX, Atlastin, AVL9, BAIAP2L1, BAIAP2L2, BRAG2, C11orf56, C14orf105, C1orf185, C1orf187, C22orf32, C2orf62, C2orf77, C4orf31, C5orf30, C9orf100, C9orf16, C9orf50, C9orf68, CACHD1, cadherin-24, Calpactin, Cdc42EP4, CHMP2, claudin-2, CNTD2, Cordon-bleu, CRIM2, Crumbs, CTU1, cytohesin-2, DC-SIGNR, DEF8, DENND2C, DENND6B, DIRAS1, DOCK 6, DOCK 7, Drac1/2, EG665186, EG667543, ELSPBP1, EPI64, EVL, Exocyst complex component (EXOC), FAM190A, FAM21C, FAM221B, FARP1, FCHSD1, FER1L5, FILIA, Flamingo, FLJ13231, FLJ45530, FND3C2, FNDC3A, FNDC8, FRAS1, gasdermin, Gbp10, Gcap14, GCC2, GDC, Gem, GFOD2, GIMAP3, GIMAP9, GLIPR1, Gm1527, Gm266, Gm600, Gm732, Gm996, GOLGA6D, HEPACAM2, HMP-2, IEX-1L, IGFN1, IQGAP2, IQSEC2, IRSp53, ISLR2, JRAB, KIAA0664, KRTAP20-3, KRTAP25-1, Laminin β-2, LHFPL1, ligatin, LIN-10, LIP5, Liprin β1, LLGL2, LMO7, LOC100041193, LOC100041222, LOC100041251, LOC100041376, LOC339209, LOC342346, LOC388284, LOC441792, LOC644978, LOC646285, LOC651033, LOC727873, LOC728222, LOC728514, LOC728651, LOC728863, LOC729251, LYPD3, MCF2L2, MDGA1, MICAL, MICAL1, MIRAB13, MS4A4B, MSE55, MTMR14, MTSS1, Munc13-4, MUP21, MUP7, MUP8, MUP9, MYL10, Myosin-13, NE-dlg, NEGR1, NET1, netrin G1, Neuroplastin, NMB, NrCAM, NYAP2, OLFML3, ORF19, OTTMUSG00000005737, p36, PAK6, Pals1, PARD3B, PARD6G, PCDH1_Pcdh1, PCDH18_Pcdh18, PCDHB12, PCDHB5, PCDHB6, PDZ-GEF1, Pet2, PHACTR2, Phocein, PLEKHG3, Plexin, plexin-B2, POP1, promethin, PSM, Punc, R-Ras, Rab 23, Rab 27b, Rab 2B, Rab 30, Rab 38, Rab 3D, Rab 43, Rab 9A, Rab 9B, Rab11-FIP1, Rab11-FIP2, Rab11-FIP3, Rab11-FIP4, Rabex-5, Rabr, Rac GAP1, racrac2, Rad GTPase, Ral BP-1, RALGAPB, Rap 1A, RAP1GDS1, RAPGEF5, RAPGEF6, RASL11B, RBM47, RGL2, RGNEF, Rho 8, Rho D, Rho G, Rho GAP p190B, Rho H, Rho J, Rho V, RILP, Rim3, RIMOC1, RIN2, RINL, RIP/Rab, Ripply2, RIPX, RPIA, RPRML, RSU1, RUNDC1, SEMA3E, SEMA4C, SEMA6C, SERINC5, SFT2D3, shootin1, Sipa1l3, Skn-1i, Slit3, Smurf2, Snap91, Syntaxin 4, syntenin-2, Tβ-4 Y-linked, TANC, TBC1D16, TBC1D19, TBC1D2, TBC1D21, TBC1D25, TBC1D26, TBC1D3, TBC1D30, TBC1D3F, TEM8, Tenascin, TGTP2, Thrombospondin 4, TMEM192, TMEM28, TNF-IP 8L2, TOCA-1, Trophinin, TSPAN8, VASP, Vav3, Vmn1r114, Vmn1r92, Vmn2r16, VWC2L, WAVE3, WDR13, WDR21B, ZNF501, ZNF608, ZNRF2, and ZSWIM6.Activator of:
2510049I19Rik, 6720456B07Rik, AFAP-1L2, ARHGAP11A, ARHGAP17, ARHGAP18, ARHGAP19, ARHGAP27_Arhgap27, ARHGAP29, ARHGAP36, ARHGAP40, ARHGAP6, ARHGEF18, ARHGEF37, ARHGEF38, ARL3, ARL8A, ARL8B, BC051019, C3orf34_1500031L02Rik, CBWD, Cdc42EP2, Cdc42EP5, CdGAP, CED-2, CED-5, Contrin, Coronin 6, Coronin 7, DDEF1, DDEFL1, DENND2A, Dist1, Dkk-4, ECT2L, EG668339, EHBP1, ENSMUSG00000071517, Eph A8, Eps8, Eps8L3, FAM21A, FAM38B, FBXW2, FGD2, FGD5, Frabin, FRMD3, girdin, Gm600, Gm732, Gm996, GRF-1, HEPACAM2, IPP-1, IQGAP3, Lfc, LRCH1, LRRCC1, MARVELD1, nephrocystin, OLFM1, PACSIN2, PAR-6, PARD6B, PDZ-RhoGEF, plexin-B3, POSH, Rab 13, Rab 19, RAb 19B, Rab 1A, Rab 3 GAP p130, Rab 33A, Rab 40C, Rab 7L1, Rab GDI β, Rab L3, RAM, RASA4B, Rho GAP p190-B, Rho GDIγ, Rho J, Rho V, Rhotekin, RICH2, RIM-BP2, SCAI, Scratch1, SEC22C, SEPT10, SGSM1, Shrm, SNX16, SNX18, SNX25, TBC1D16, TBC1D20, TBC1D22A, TC10, Tom1, VPS11, WAVE2, ZFYVE1, and Zizimin-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NSC 23766, 10 mg | sc-204823 | 10 mg | $151.00 | |||
NSC 23766, 50 mg | sc-204823A | 50 mg | $609.00 |