QKI Inhibitors
QKI inhibitors belong to a distinct chemical class that has garnered significant attention in the realm of molecular biology and cellular signaling. The term QKI refers to the quaking homolog, a family of RNA-binding proteins crucial for the regulation of post-transcriptional events. QKI proteins play a pivotal role in RNA splicing, stability, and transport, influencing the intricate orchestration of gene expression. The inhibitors specifically target the QKI proteins, disrupting their normal function and, consequently, modulating downstream cellular processes.
QKI inhibitors are designed to interfere with the binding affinity of QKI proteins to RNA molecules. By obstructing these interactions, the inhibitors exert a regulatory effect on RNA processing, potentially leading to alterations in alternative splicing patterns or mRNA stability. The underlying rationale for developing QKI inhibitors lies in the recognition of the pivotal role QKI proteins play in various cellular functions, including myelination in the nervous system and the maintenance of cellular homeostasis. As researchers delve deeper into the intricate mechanisms governing RNA biology, QKI inhibitors emerge as valuable tools for elucidating the precise molecular pathways underpinning cellular processes, shedding light on the intricate web of interactions that shape gene expression patterns and cellular functions.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a potent and selective inhibitor of MEK, a kinase upstream of QKI in several signaling pathways. Inhibition of MEK can lead to decreased phosphorylation and activation of QKI. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is another MEK inhibitor that can indirectly inhibit QKI activity by affecting its phosphorylation status. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, which can affect Akt signaling, a pathway that may interface with QKI. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor that can indirectly affect QKI. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor, a pathway that can cross-talk with others that QKI is involved in, leading to indirect inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. QKI may be indirectly affected by changes in p38 MAPK signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor, which might indirectly regulate QKI through crosstalk with relevant pathways. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a Rho-associated protein kinase inhibitor, which can affect cytoskeletal organization and potentially influence QKI. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $136.00 | 20 | |
KN-62 is a selective inhibitor of calcium/calmodulin-dependent protein kinase II, which may indirectly affect QKI. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor and can indirectly influence QKI by affecting tyrosine kinase-dependent pathways. | ||||||