Pyhin1 Inhibitors
Chemical inhibitors of Pyhin1 operate through various mechanisms to impede the protein's function in inflammatory processes. Z-VAD-FMK and VX-765 are pan-caspase and selective caspase-1 inhibitors, respectively. They can inhibit Pyhin1 by preventing the activation of caspase-1, an enzyme critical for the cleavage of pro-inflammatory cytokines and a component of the inflammasome complex to which Pyhin1 contributes. These inhibitors collectively target a crucial step in the signaling cascade that enables Pyhin1 to promote inflammation. MCC950 and CRID3, both NLRP3 inflammasome inhibitors, can suppress the assembly and activation of the inflammasome, a multiprotein oligomer that plays a pivotal role in innate immunity and inflammation, which Pyhin1 influences through its involvement.
Meanwhile, compounds like Parthenolide and Bay 11-7082 can hinder Pyhin1 by disrupting the NF-κB pathway. Parthenolide can target the pathway by reducing the inflammatory response, while Bay 11-7082 prevents the phosphorylation of IκBα, a process that is necessary for the activation of NF-κB. By inhibiting these pathways, they restrict Pyhin1's ability to modulate inflammation. Furthermore, Anakinra, an IL-1 receptor antagonist, can limit the functional effects of Pyhin1 by binding to the IL-1 receptor and preventing the action of IL-1, a cytokine whose release is facilitated by Pyhin1. Infliximab, a TNFα inhibitor, can directly block the activity of TNFα, another cytokine involved in inflammatory responses where Pyhin1 has a regulatory role. Glibenclamide can inhibit ATP-sensitive potassium channels, which are implicated in the regulation of the inflammasome and, indirectly, Pyhin1's activity. Lastly, PDTC, an inhibitor of NF-κB, can suppress the activation of NF-κB-mediated inflammatory responses, which are processes influenced by Pyhin1. These chemical inhibitors collectively work to inhibit the functional role of Pyhin1 in inflammation by targeting different aspects of its regulatory mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $74.00 | 256 | |
This is a pan-caspase inhibitor that can inhibit Pyhin1 by preventing the caspase-1 activation, which is a part of the inflammasome complex that Pyhin1 is involved in. Inhibition of caspase-1 would prevent the processing of pro-inflammatory cytokines, which is a key function of the inflammasome, thereby functionally inhibiting Pyhin1's role in this pathway. | ||||||
VX-765 | 273404-37-8 | sc-475845 sc-475845A sc-475845B | 5 mg 10 mg 50 mg | $224.00 $296.00 $949.00 | 1 | |
VX-765 is a selective caspase-1 inhibitor that could inhibit the function of Pyhin1 by blocking the activation of caspase-1 and the subsequent production of IL-1β, which Pyhin1 is known to influence through its involvement in the inflammasome. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide can inhibit Pyhin1 by targeting the NF-κB pathway, which is involved in the regulation of inflammation and apoptosis, processes in which Pyhin1 is implicated. By inhibiting this pathway, parthenolide would reduce the inflammatory response that Pyhin1 is part of, thereby inhibiting its function. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
This chemical inhibits NF-κB activation by blocking phosphorylation of IκBα without affecting IκBα degradation, thereby inhibiting the pathway in which Pyhin1 is involved. This would functionally inhibit Pyhin1 by reducing its ability to modulate NF-κB-mediated inflammatory responses. | ||||||
Anakinra | 143090-92-0 | sc-507486 | 10 mg | $795.00 | ||
Anakinra is an IL-1 receptor antagonist that inhibits the activity of IL-1, a cytokine whose maturation and release is promoted by Pyhin1 through the inflammasome. By inhibiting the receptor for IL-1, Anakinra would reduce the functional effects of Pyhin1's role in promoting inflammation. | ||||||
Glyburide (Glibenclamide) | 10238-21-8 | sc-200982 sc-200982A sc-200982D sc-200982B sc-200982C | 1 g 5 g 25 g 100 g 500 g | $45.00 $60.00 $115.00 $170.00 $520.00 | 36 | |
Glibenclamide can inhibit the ATP-sensitive potassium channels, which have been implicated in the regulation of the inflammasome. Inhibition of these channels could thereby inhibit Pyhin1 by preventing the potassium efflux that is important for inflammasome activation, a process in which Pyhin1 is involved. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $32.00 $63.00 | 11 | |
Pyrrolidine dithiocarbamate (PDTC) is an NF-κB inhibitor that could inhibit Pyhin1 by preventing the activation of NF-κB, a transcription factor involved in the regulation of the inflammatory response with which Pyhin1 is associated. This would inhibit the NF-κB-dependent inflammatory processes that Pyhin1 can influence. | ||||||