PU.1 Inhibitors
Common PU.1 Inhibitors include, but are not limited to Chlormadinone Acetate CAS 302-22-7, Tanshinone IIA CAS 568-72-9, Cortisone CAS 53-06-5, Clofarabine CAS 123318-82-1 and Caffeic Acid CAS 331-39-5.
PU.1 inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of the PU.1 transcription factor. PU.1 is a member of the ETS family of transcription factors and plays a critical role in the regulation of hematopoiesis and immune cell development. It is involved in the activation or repression of genes that influence the differentiation and function of various immune cells, including B cells, T cells, and myeloid cells.
PU.1 inhibitors work by specifically targeting the PU.1 transcription factor, interfering with its ability to bind to DNA and regulate the expression of target genes. By doing so, these inhibitors may modulate the transcriptional activity of PU.1 and impact the development and function of immune cells. Research into PU.1 and its inhibitors is ongoing to unravel their precise mechanisms of action and explore their implications in cellular processes. The study of PU.1 inhibitors represents an intriguing area of research, contributing to a deeper understanding of the intricate mechanisms governing hematopoiesis and immune cell differentiation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chlormadinone Acetate | 302-22-7 | sc-211070 | 10 mg | $136.00 | ||
Downregulates PU.1 expression, impeding its function as a transcription factor and modulating immune responses. | ||||||
Tanshinone IIA | 568-72-9 | sc-200932 sc-200932A | 5 mg 25 mg | $88.00 $316.00 | 22 | |
Suppresses PU.1 DNA-binding activity and its interaction with co-activators, resulting in decreased transcription of target genes. | ||||||
Cortisone | 53-06-5 | sc-207455 | 5 g | $230.00 | ||
Interferes with PU.1 binding to DNA, disrupting its transcriptional regulation and altering immune cell differentiation and function. | ||||||
Clofarabine | 123318-82-1 | sc-278864 sc-278864A | 10 mg 50 mg | $185.00 $781.00 | ||
Inhibits PU.1 activity by inducing apoptosis and interfering with its DNA-binding ability, affecting immune cell development. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $32.00 $62.00 | 1 | |
Reduces PU.1 expression and DNA-binding activity, leading to altered transcriptional regulation and immune responses. | ||||||
Carbenoxolone | 5697-56-3 | sc-507294 | 1 g | $50.00 | ||
Downregulates PU.1 expression and disrupts its binding to target gene promoters, modulating inflammatory responses and immune function. | ||||||