PRTFDC1 Activators
PRTFDC1 Activators consist of various chemical compounds that indirectly upregulate the functional activity of PRTFDC1 through their influence on the purine salvage pathway and the availability of substrates and cofactors. Adenosine monophosphate (AMP) and dipyridamole, by increasing intracellular AMP levels, provide the necessary substrate for PRTFDC1's reaction, thus enhancing its enzymatic activity. Similarly, inosine contributes to the pool of substrates directly utilized by PRTFDC1. The presence of zinc sulfate and magnesium chloride provides essential cofactors that are crucial for the optimal catalytic function of PRTFDC1. In addition, compounds such as nicotinamide adenine dinucleotide (NAD+) and folic acid indirectly support the activity of PRTFDC1 by ensuring an adequate supply of purine nucleotides, which are necessary for its function. Glycine and glutamine serve as precursors in the de novo synthesis of purines, thereby indirectly increasing the availability of substrates for PRTFDC1's enzymatic action. Methotrexate, by inhibiting dihydrofolate reductase, leads to a compensatory increase in purine synthesis, which indirectly upregulates PRTFDC1 activity by boosting substrate levels.
The activity of PRTFDC1 is further influenced by chemicals that directly provide substrates or modulate their levels within the purine metabolic pathways. 5-Phosphoribosyl 1-pyrophosphate (PRPP) directly enhances PRTFDC1 by serving as a phosphate donor for the enzymatic reactions it catalyzes. Allopurinol, through its inhibition of xanthine oxidase, increases the concentration of hypoxanthine and xanthine, both of which are substrates in the purine salvage pathway, thereby enhancing PRTFDC1 activity by substrate availability. These activators collectively ensure that PRTFDC1 operates efficiently within the purine salvage pathway by either supplying essential substrates or cofactors, or by influencing the synthesis and metabolism of purines, leading to an increased functional throughput of the enzyme without necessitating changes in its expression levels.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine phosphate(Vitamin B8) | 61-19-8 | sc-278678 sc-278678A | 50 g 100 g | $160.00 $240.00 | ||
AMP serves as a signaling molecule in various cellular processes. It can increase the activity of PRTFDC1, which has phosphoribosyltransferase activity, by providing the necessary substrate for the reaction that PRTFDC1 catalyzes. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is a cofactor for many enzymes, including PRTFDC1. By supplementing with Zinc sulfate, the catalytic activity of PRTFDC1, which is dependent on the availability of zinc ions, can be enhanced. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Magnesium ions act as cofactors for many enzymes, including those involved in nucleotide metabolism. By increasing the availability of magnesium, the enzymatic function of PRTFDC1 can be enhanced. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ is a cofactor in redox reactions and is involved in the metabolism of purines. PRTFDC1, which is implicated in purine metabolism, could have its activity enhanced in the presence of adequate amounts of NAD+. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $72.00 | 2 | |
Folic acid is essential for the synthesis of purines. As PRTFDC1 is part of the purine salvage pathway, the presence of folic acid can indirectly enhance the activity of PRTFDC1 by increasing the pool of purine nucleotides. | ||||||
Inosine | 58-63-9 | sc-295182 sc-295182A | 1 g 5 g | $59.00 $90.00 | ||
Inosine can serve as a substrate in the purine salvage pathway, where PRTFDC1 functions. Providing inosine can enhance the activity of PRTFDC1 by increasing the availability of substrates for its enzymatic action. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $40.00 $70.00 $110.00 $350.00 | 15 | |
Glycine is a precursor in the synthesis of purines. By increasing the availability of glycine, the purine synthesis pathway can be upregulated, indirectly enhancing the activity of PRTFDC1 through increased substrate availability. | ||||||
L-Glutamine | 56-85-9 | sc-391013 sc-391013C sc-391013A sc-391013D sc-391013B | 100 g 250 g 1 kg 5 kg 10 kg | $36.00 $46.00 $97.00 $372.00 $719.00 | 2 | |
Glutamine serves as a nitrogen donor in the synthesis of purine rings. Supplementing with glutamine could potentially enhance the activity of PRTFDC1 by ensuring sufficient purine synthesis, which in turn provides substrates for PRTFDC1's enzymatic function. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate is a known inhibitor of dihydrofolate reductase, leading to increased levels of dihydrofolate and a subsequent increase in purine synthesis to compensate. This indirect effect can enhance the activity of PRTFDC1 by providing more substrate for its enzymatic conversion. | ||||||
Dipyridamole | 58-32-2 | sc-200717 sc-200717A | 1 g 5 g | $30.00 $100.00 | 1 | |
Dipyridamole inhibits phosphodiesterase, leading to increased AMP levels. The increase in AMP can enhance the activity of PRTFDC1 by providing more of its substrate for the salvage of purines. | ||||||