Proliferin-1 Inhibitors
Chemical inhibitors of Proliferin-1 function through various biochemical pathways to impede its role in cell proliferation and angiogenesis. 2-Methoxyestradiol, a metabolite of estradiol, can inhibit angiogenesis, a process essential for providing nutrients to proliferating cells. This action limits the ability of Proliferin-1 to promote cell growth by reducing the availability of necessary growth factors. Similarly, Suramin, by inhibiting growth factor receptors, can disrupt the signaling that Proliferin-1 relies on to exert its proliferative effects. Pazopanib and Sunitinib, as multi-target tyrosine kinase inhibitors, can obstruct Proliferin-1's role by impeding the kinase activity crucial for signaling processes that mediate cell proliferation and vascular growth. Sorafenib extends this inhibition by targeting several receptors involved in the signaling pathways, further halting the proliferation and angiogenesis that Proliferin-1 is known to facilitate.
In addition to the above, Bevacizumab indirectly inhibits Proliferin-1 by neutralizing VEGF, a vital growth factor in angiogenesis, thereby reducing signals that promote vascular growth. Thalidomide can also inhibit Proliferin-1 through its anti-angiogenic properties, which prevent the development of a necessary blood supply for proliferating cells. Erlotinib and Gefitinib, both EGFR inhibitors, can disrupt the cell signaling pathways integral to cellular growth, thereby inhibiting the function of Proliferin-1. Bortezomib's proteasome inhibition can lead to the stabilization of cell cycle inhibitory proteins, which in turn can impede the cell cycle progression influenced by Proliferin-1. Marimastat contributes to the inhibition by targeting the matrix metalloproteinases, thereby blocking extracellular matrix remodeling required for angiogenesis. Lastly, Vandetanib's inhibition of multiple tyrosine kinases, including VEGFR, EGFR, and RET, can inhibit Proliferin-1 by interfering with the signaling pathways that are involved in cell growth and angiogenesis, delineating a comprehensive approach to the functional inhibition of this protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $71.00 $288.00 | 6 | |
As a natural metabolite of estradiol, 2-Methoxyestradiol can inhibit angiogenesis, which is crucial for providing nutrients and oxygen to proliferating cells. Since Proliferin-1 is involved in angiogenesis and cell proliferation, this chemical can lead to functional inhibition of Proliferin-1 by starving the proliferating cells of essential growth factors. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Suramin is an inhibitor of various growth factor receptors. By binding to these receptors, it inhibits the binding and activity of growth factors that are necessary for cell proliferation. Since Proliferin-1 is implicated in cell growth, Suramin can inhibit its function by blocking the signaling pathways that Proliferin-1 would normally activate. | ||||||
Pazopanib | 444731-52-6 | sc-396318 sc-396318A | 25 mg 50 mg | $130.00 $182.00 | 2 | |
Pazopanib is a multi-target tyrosine kinase inhibitor that interferes with angiogenesis. It can functionally inhibit Proliferin-1 by blocking the kinase activity required for the signaling processes that mediate cell proliferation and vascular growth. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $153.00 $938.00 | 5 | |
Sunitinib is another tyrosine kinase inhibitor with anti-angiogenic properties. It can inhibit Proliferin-1 by obstructing the kinase-driven signaling mechanisms essential for the proliferation of cells and new blood vessel formation. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide has been found to possess anti-angiogenic properties, inhibiting the growth of new blood vessels. This can lead to functional inhibition of Proliferin-1 by preventing the establishment of a blood supply necessary for cell proliferation. | ||||||
Erlotinib, Free Base | 183321-74-6 | sc-396113 sc-396113A sc-396113B sc-396113C sc-396113D | 500 mg 1 g 5 g 10 g 100 g | $87.00 $135.00 $293.00 $505.00 $3827.00 | 42 | |
Erlotinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. By inhibiting EGFR, erlotinib can inhibit Proliferin-1 by blocking the cell signaling pathways that are involved in cellular growth and proliferation. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib is a kinase inhibitor that targets several receptors, including VEGFR, PDGFR, and Raf kinases. By inhibiting these kinases, Sorafenib can functionally inhibit Proliferin-1 by halting cell proliferation and angiogenesis. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib, a proteasome inhibitor, can indirectly inhibit Proliferin-1 by preventing the degradation of inhibitory proteins that regulate cell cycle progression and proliferation. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
Marimastat is a matrix metalloproteinase inhibitor that can inhibit Proliferin-1 by blocking the enzymes responsible for extracellular matrix remodeling, which is a requirement for angiogenesis and tumor growth. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $63.00 $114.00 $218.00 $349.00 | 74 | |
Gefitinib is an EGFR inhibitor that prevents the phosphorylation of tyrosine kinases associated with EGFR, which can functionally inhibit Proliferin-1 by disrupting cellular pathways needed for proliferation. | ||||||