PRODH Activators
The chemical class of PRODH Activators includes compounds that can indirectly influence the function of PRODH through various mechanisms related to energy metabolism, cellular redox states, and substrate availability. These compounds, while not directly interacting with PRODH, play significant roles in modulating the cellular environment and metabolic pathways that can lead to the activation or upregulation of PRODH's function.
Substrates and products of the Krebs cycle, such as Alpha-Ketoglutarate, Succinic Acid, Sodium Pyruvate, Malate, and Fumarate, can influence cellular energy states, which in turn may modulate PRODH activity. This modulation is pivotal because PRODH is intricately linked to cellular energy metabolism through its role in proline degradation. Antioxidants like N-Acetylcysteine, Glutathione, and Ascorbic Acid can impact PRODH activity by altering the cellular redox state. PRODH, being involved in oxidative metabolism, is likely sensitive to changes in the cellular redox environment. Moreover, the availability of its substrate, L-Proline, and the accumulation of its product, P5C, can serve as feedback mechanisms that modulate the enzyme's activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Pyroglutamic acid | 98-79-3 | sc-255245 sc-255245A sc-255245B | 25 g 100 g 1 kg | $29.00 $61.00 $178.00 | ||
As the product of PRODH's enzymatic action, P5C can potentially feedback-regulate PRODH to enhance its activity. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
An antioxidant that can reduce oxidative stress, potentially influencing PRODH activity as part of the cellular stress response. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $76.00 $2050.00 | 8 | |
Another antioxidant that may affect PRODH activity by modulating cellular redox states. | ||||||
L-Proline | 147-85-3 | sc-397196 sc-397196A sc-397196B sc-397196C | 25 g 100 g 1 kg 5 kg | $37.00 $130.00 $204.00 $959.00 | ||
Substrate availability can influence enzymatic activity; increased proline levels may enhance PRODH activity. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
An antioxidant that can affect cellular redox state, potentially influencing PRODH activity. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $32.00 $42.00 $62.00 $108.00 $184.00 $724.00 $2050.00 | 2 | |
Involved in the Krebs cycle; can influence energy metabolism pathways that may indirectly modulate PRODH activity. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $44.00 $74.00 $130.00 | ||
A Krebs cycle intermediate; its levels can affect cellular energy states and indirectly influence PRODH activity. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Involved in mitochondrial electron transport, can affect cellular energy states and potentially modulate PRODH activity. | ||||||
Malic acid | 6915-15-7 | sc-257687 | 100 g | $127.00 | 2 | |
Another Krebs cycle intermediate; can influence PRODH activity by modulating cellular energy states. | ||||||
Fumaric acid | 110-17-8 | sc-250031 sc-250031A sc-250031B sc-250031C | 25 g 100 g 500 g 2.5 kg | $42.00 $56.00 $112.00 $224.00 | ||
A Krebs cycle component; its modulation of energy metabolism can indirectly affect PRODH activity. | ||||||