Date published: 2026-6-8

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PRODH Inhibitors

PRODH inhibitors comprise a diverse array of compounds that have been strategically designed to modulate the activity of proline dehydrogenase (PRODH), an enzyme central to proline metabolism. These inhibitors are meticulously developed through a convergence of molecular insights and mechanistic understanding, often employing sophisticated techniques such as computational modeling, high-throughput screening, and chemical synthesis. The primary aim is to precisely engineer compounds that selectively target PRODH, influencing its role in catalyzing the conversion of proline to Δ1-pyrroline-5-carboxylate (P5C). By targeting PRODH, these inhibitors provide valuable tools for unraveling the intricate mechanisms that underlie proline metabolism, shedding light on the nuanced dynamics that govern cellular responses involving proline. The exploration of PRODH inhibitors contributes to a deeper understanding of the finely tuned interactions within the proline metabolic pathway, offering insights into the molecular orchestration that orchestrates the balance between proline utilization and cellular processes.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Tetrahydro-2-furoic acid

16874-33-2sc-253674
5 g
$41.00
1
(0)

Tetrahydro-2-furoic acid exhibits intriguing reactivity as an acid halide, characterized by its ability to engage in nucleophilic acyl substitution reactions. The presence of the furan ring enhances its electrophilic nature, allowing for selective interactions with various nucleophiles. Its unique steric and electronic properties facilitate rapid reaction kinetics, making it a versatile intermediate in synthetic pathways. Additionally, the compound's solubility in polar solvents promotes efficient mixing and reaction rates in diverse chemical environments.

L-Selenomethionine

3211-76-5sc-204050
sc-204050A
250 mg
1 g
$223.00
$597.00
1
(1)

This naturally occurring amino acid has been studied for its potential inhibitory effects on PRODH and its impact on proline metabolism.

Quinolinic acid

89-00-9sc-203226
1 g
$32.00
7
(1)

An intermediate in the kynurenine pathway, quinolinic acid has been explored for its potential inhibitory effects on PRODH.

Benomyl

17804-35-2sc-239286B
sc-239286
sc-239286A
1 g
5 g
25 g
$102.00
$141.00
$447.00
1
(1)

An agricultural fungicide, benomyl has been studied for its potential impact on PRODH activity and proline metabolism in plants.

Acivicin

42228-92-2sc-200498B
sc-200498C
sc-200498
sc-200498D
1 mg
5 mg
10 mg
25 mg
$104.00
$416.00
$655.00
$1301.00
10
(2)

An experimental compound, AT-125 has been investigated for its potential inhibitory effects on PRODH and its impact on proline metabolism.

Fenamidone

161326-34-7sc-228111
100 mg
$77.00
(0)

This fungicide has been studied for its potential to inhibit PRODH and modulate proline metabolism in fungi.

PX 12

141400-58-0sc-358518
sc-358518A
10 mg
50 mg
$133.00
$505.00
9
(1)

This experimental compound has been investigated for its potential inhibitory effects on PRODH and its impact on oxidative stress pathways.

Levodopa

59-92-7sc-205372
sc-205372A
5 g
25 g
$54.00
$171.00
9
(1)

L-DOPA has been studied for its potential inhibitory effects on PRODH and its impact on proline metabolism.

L-Mimosine

500-44-7sc-201536A
sc-201536B
sc-201536
sc-201536C
25 mg
100 mg
500 mg
1 g
$36.00
$88.00
$220.00
$436.00
8
(2)

This natural compound has been explored for its potential interactions with PRODH and its impact on proline metabolism.