prefoldin 5 Activators
Prefoldin 5 Activators belong to a distinct chemical class characterized by their ability to modulate the activity of Prefoldin 5 (PFDN5), a critical protein complex involved in protein folding and assembly within the cell. Prefoldin 5, also known as PFDN5 or Gim3p, is a conserved protein found in eukaryotic organisms, and it plays a crucial role in maintaining cellular homeostasis. The activators of Prefoldin 5, although diverse in structure, share a common function in regulating the function of PFDN5 and influencing cellular processes.
These activators interact with Prefoldin 5 at a molecular level, either by binding to it directly or through other proteins in the cell. Their binding can induce conformational changes in Prefoldin 5, leading to alterations in its ability to chaperone and assist in protein folding. This, in turn, affects the overall proteostasis of the cell, impacting the correct folding and assembly of various proteins. Prefoldin 5 Activators may enhance or inhibit the chaperone activity of Prefoldin 5, thereby influencing protein folding pathways and potentially contributing to cellular responses to stress or environmental cues. Understanding the precise mechanisms and structural details of these activators is of great interest to researchers in cell biology and biochemistry, as it can shed light on fundamental processes governing protein homeostasis within cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which could enhance the chaperone activity of Prefoldin 5 by promoting proper folding and stabilization of target proteins. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase-4, thereby preventing cAMP degradation, potentially increasing Prefoldin 5 activity by maintaining protein stability and assisting in proper folding. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, increasing cAMP concentrations, which may indirectly boost Prefoldin 5's function in stabilizing nascent polypeptides. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Zaprinast inhibits phosphodiesterase-5, contributing to increased cGMP levels, which could indirectly promote Prefoldin 5-mediated protein folding through cGMP-dependent protein kinase signaling. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 selectively inhibits ROCK, which can enhance cytoskeletal dynamics, potentially facilitating Prefoldin 5 involvement in the structural maintenance of client proteins. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin inhibits myosin II, altering cytoskeletal dynamics and potentially improving Prefoldin 5's ability to stabilize and fold cytoskeletal-associated proteins. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 inhibits myosin light chain kinase, which may influence cytoskeletal organization and could enhance Prefoldin 5's role in supporting proper protein folding. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine disrupts microtubule formation, which might enhance Prefoldin 5's chaperone activity as it helps in stabilizing client proteins during cellular stress. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules, potentially aiding Prefoldin 5 in its role of ensuring proper protein folding and maintenance in the cellular cytoskeleton. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide stabilizes actin filaments, potentially improving Prefoldin 5's chaperone activity by enhancing the structural integrity of proteins associated with the cytoskeleton. | ||||||