prefoldin 5 Antibody (B-11): sc-271150
- prefoldin 5 Antibody (B-11) is a mouse monoclonal IgG1 κ prefoldin 5 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-154 representing full length prefoldin 5 of human origin
- prefoldin 5 Antibody (B-11) is recommended for detection of prefoldin 5 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-prefoldin 5 Antibody (B-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for prefoldin 5 Antibody (B-11) for WB and IHC(P) applications. This reagent is now offered in a bundle with prefoldin 5 Antibody (B-11) (see ordering information below).
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Prefoldin 5 Antibody (B-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects prefoldin 5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-prefoldin 5 antibody (B-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Prefoldin 5 plays a crucial role in protein folding, acting as a molecular chaperone that assists in proper protein assembly, particularly in the crowded cytoplasm environment. Prefoldin 5 belongs to a family of prefoldins, which are heterohexameric complexes that capture unfolded proteins and facilitate transfer to chaperonins for correct folding. Prefoldin 5 specifically interacts with c-Myc, a transcription factor involved in cell proliferation and growth, highlighting prefoldin 5′s importance in regulating cellular functions and maintaining homeostasis. Prefoldin 5′s ability to bind c-Myc suggests a significant role in oncogenic processes, making prefoldin 5 a valuable target for cancer biology research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
prefoldin 5 Antibody (B-11) References:
- MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer. | Fujioka, Y., et al. 2001. J Biol Chem. 276: 45137-44. PMID: 11567024
- A novel transrepression pathway of c-Myc. Recruitment of a transcriptional corepressor complex to c-Myc by MM-1, a c-Myc-binding protein. | Satou, A., et al. 2001. J Biol Chem. 276: 46562-7. PMID: 11585818
- Distinct localizations and repression activities of MM-1 isoforms toward c-Myc. | Hagio, Y., et al. 2006. J Cell Biochem. 97: 145-55. PMID: 16173081
- MM-1 facilitates degradation of c-Myc by recruiting proteasome and a novel ubiquitin E3 ligase. | Kimura, Y., et al. 2007. Int J Oncol. 31: 829-36. PMID: 17786314
- Negative regulation of the Wnt signal by MM-1 through inhibiting expression of the wnt4 gene. | Yoshida, T., et al. 2008. Exp Cell Res. 314: 1217-28. PMID: 18281035
- Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product. | Tsuchiya, H., et al. 1996. Cancer Res. 56: 2881-5. PMID: 8674032
- Characterization of the gene (VBP1) and transcript for the von Hippel-Lindau binding protein and isolation of the highly conserved murine homologue. | Brinke, A., et al. 1997. Genomics. 45: 105-12. PMID: 9339366
- Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. | Vainberg, IE., et al. 1998. Cell. 93: 863-73. PMID: 9630229
- MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc. | Mori, K., et al. 1998. J Biol Chem. 273: 29794-800. PMID: 9792694
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
prefoldin 5 Antibody (B-11) | sc-271150 | 200 µg/ml | $322.00 | |||
prefoldin 5 Antibody (B-11): m-IgG Fc BP-HRP Bundle | sc-525789 | 200 µg Ab; 10 µg BP | $361.00 | |||
prefoldin 5 Antibody (B-11) AC | sc-271150 AC | 500 µg/ml, 25% agarose | $424.00 | |||
prefoldin 5 Antibody (B-11) HRP | sc-271150 HRP | 200 µg/ml | $322.00 | |||
prefoldin 5 Antibody (B-11) FITC | sc-271150 FITC | 200 µg/ml | $336.00 | |||
prefoldin 5 Antibody (B-11) PE | sc-271150 PE | 200 µg/ml | $349.00 | |||
prefoldin 5 Antibody (B-11) Alexa Fluor® 488 | sc-271150 AF488 | 200 µg/ml | $364.00 | |||
prefoldin 5 Antibody (B-11) Alexa Fluor® 546 | sc-271150 AF546 | 200 µg/ml | $364.00 | |||
prefoldin 5 Antibody (B-11) Alexa Fluor® 594 | sc-271150 AF594 | 200 µg/ml | $364.00 | |||
prefoldin 5 Antibody (B-11) Alexa Fluor® 647 | sc-271150 AF647 | 200 µg/ml | $364.00 | |||
prefoldin 5 Antibody (B-11) Alexa Fluor® 680 | sc-271150 AF680 | 200 µg/ml | $364.00 | |||
prefoldin 5 Antibody (B-11) Alexa Fluor® 790 | sc-271150 AF790 | 200 µg/ml | $364.00 |