POP1 Activators
The chemical activators listed for POP1 primarily target pathways related to protein folding, stress responses, and cellular homeostasis, providing an indirect means of influencing POP1 activity. Cyclophilins, the family of proteins to which POP1 belongs, have a key role in protein folding due to their peptidyl-prolyl isomerase activity. Compounds like Cyclosporin A and FK506 can have complex effects in cellular contexts, modulating POP1 activity indirectly.
Geldanamycin and 17-AAG affect the protein folding machinery by inhibiting Heat Shock Protein 90, a crucial chaperone in the cell. This can lead to altered protein folding landscapes and possibly influence the activity of cyclophilins like POP1. Compounds affecting the NF-kB pathway and ER stress modulators also play a role in cellular stress responses. By modulating these pathways, they can indirectly influence the environment in which POP1 operates, affecting its activity. Additionally, autophagy modulators, which influence protein turnover, can alter the cellular context in which POP1 functions, providing another route for indirect modulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
A known inhibitor of cyclophilins; though primarily an inhibitor, it could potentially modulate POP1 activity in a complex cellular context. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
Another immunosuppressant that inhibits cyclophilins, potentially affecting POP1 indirectly. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, which can influence protein folding and stress responses, potentially impacting POP1 function. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
A Hsp90 inhibitor, which affects protein folding pathways and might indirectly influence POP1 activity. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
Similar to Geldanamycin, as an Hsp90 inhibitor, it may impact protein folding and indirectly affect POP1. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Disrupts microtubule polymerization, potentially affecting cellular stress responses and indirectly POP1. | ||||||
CCT 018159 | 171009-07-7 | sc-202526 | 5 mg | $93.00 | ||
These inhibitors affect protein folding mechanisms and could indirectly impact POP1 activity. | ||||||